Atopic Dermatitis as a Multifactorial Skin Disorder. Can the Analysis of Pathophysiological Targets Represent the Winning Therapeutic Strategy?

Atopic dermatitis (AD) is a pathological skin condition with complex aetiological mechanisms that are difficult to fully understand. Scientific evidence suggests that of all the causes, the impairment of the skin barrier and cutaneous dysbiosis together with immunological dysfunction can be consider...

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Bibliographic Details
Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2020-11, Vol.13 (11), p.411
Main Authors: Magnifico, Irene, Petronio Petronio, Giulio, Venditti, Noemi, Cutuli, Marco Alfio, Pietrangelo, Laura, Vergalito, Franca, Mangano, Katia, Zella, Davide, Di Marco, Roberto
Format: Article
Language:English
Subjects:
atopic dermatitis
cutaneous dysbiosis
Cytokines
Dermatitis
drug delivery systems
Homeostasis
Inflammation
Lipids
microbial therapy
Microbiota
Microorganisms
Pathogens
Phenols
Physiology
Probiotics
Proteins
Pruritus
Review
skin barrier
Skin diseases
Staphylococcus aureus
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Summary:Atopic dermatitis (AD) is a pathological skin condition with complex aetiological mechanisms that are difficult to fully understand. Scientific evidence suggests that of all the causes, the impairment of the skin barrier and cutaneous dysbiosis together with immunological dysfunction can be considered as the two main factors involved in this pathological skin condition. The loss of the skin barrier function is often linked to dysbiosis and immunological dysfunction, with an imbalance in the ratio between the pathogen and/or other microorganisms residing in the skin. The bibliographic research was conducted on PubMed, using the following keywords: 'atopic dermatitis', 'bacterial therapy', 'drug delivery system' and 'alternative therapy'. The main studies concerning microbial therapy, such as the use of bacteria and/or part thereof with microbiota transplantation, and drug delivery systems to recover skin barrier function have been summarized. The studies examined show great potential in the development of effective therapeutic strategies for AD and AD-like symptoms. Despite this promise, however, future investigative efforts should focus both on the replication of some of these studies on a larger scale, with clinical and demographic characteristics that reflect the general AD population, and on the process of standardisation, in order to produce reliable data.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph13110411