Discovery of Myeloid-Derived Suppressor Cell-Specific Metabolism by Metabolomic and Lipidomic Profiling

The endogenous factors that control the differentiation of myeloid-derived suppressor cells (MDSCs) are not yet fully understood. The purpose of this study was to find MDSC-specific biomolecules through comprehensive metabolomic and lipidomic profiling of MDSCs from tumor-bearing mice and to discove...

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Bibliographic Details
Published in:Metabolites 2023-03, Vol.13 (4), p.477
Main Authors: Kim, Jisu, Lee, Hwanhui, Choi, Hyung-Kyoon, Min, Hyeyoung
Format: Article
Language:English
Subjects:
Apoptosis
Cancer
Carrier proteins
Cell differentiation
Cell metabolism
Cloning
Cytotoxicity
Dendritic cells
Development and progression
Discriminant analysis
Glucose metabolism
Health aspects
Lecithin
lipidomics
Lipids
Lipogenesis
Lymphocytes
Mass spectrometry
Metabolism
Metabolites
Metabolomics
myeloid-derived suppressor cell
Phosphatidylcholine
Phosphatidylethanolamine
Physiological aspects
Proteins
Putrescine
Scientific imaging
Software
Spleen
Suppressor cells
Therapeutic applications
Therapeutic targets
Tryptophan
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Summary:The endogenous factors that control the differentiation of myeloid-derived suppressor cells (MDSCs) are not yet fully understood. The purpose of this study was to find MDSC-specific biomolecules through comprehensive metabolomic and lipidomic profiling of MDSCs from tumor-bearing mice and to discover potential therapeutic targets for MDSCs. Partial least squares discriminant analysis was performed on the metabolomic and lipidomic profiles. The results showed that inputs for the serine, glycine, and one-carbon pathway and putrescine are increased in bone marrow (BM) MDSC compared to normal BM cells. Splenic MDSC showed an increased phosphatidylcholine to phosphatidylethanolamine ratio and less de novo lipogenesis products, despite increased glucose concentration. Furthermore, tryptophan was found to be at the lowest concentration in splenic MDSC. In particular, it was found that the concentration of glucose in splenic MDSC was significantly increased, while that of glucose 6-phosphate was not changed. Among the proteins involved in glucose metabolism, GLUT1 was overexpressed during MDSC differentiation but decreased through the normal maturation process. In conclusion, high glucose concentration was found to be an MDSC-specific feature, and it was attributed to GLUT1 overexpression. These results will help to develop new therapeutic targets for MDSCs.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo13040477