Pharmacogenomics and Pharmacogenetics: In Silico Prediction of Drug Effects in Treatments for Novel Coronavirus SARS-CoV2 Disease

The latest developments in precision medicine allow the modulation of therapeutic approaches in different pathologies on the basis of the specific molecular characterization of the patient. This review of the literature coupled with in silico analysis was to provide a selected screening of interacti...

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Bibliographic Details
Published in:Pharmacogenomics and personalized medicine 2020-01, Vol.13, p.463-484
Main Authors: Cafiero, Concetta, Re, Agnese, Micera, Alessandra, Palmirotta, Raffaele, Monaco, Delio, Romano, Francesca, Fabrizio, Claudia, Di Francia, Raffaele, Cacciamani, Andrea, Surico, Pier Luigi, D'Amato, Gerardo, Pisconti, Salvatore
Format: Article
Language:English
Subjects:
adr
Clinical trials
Coronaviruses
COVID-19
Cytokines
Disease transmission
Drug dosages
drug effects
Drug therapy
Evolution
FDA approval
Genetic analysis
Genetic diversity
Genomes
in-silico
Infections
Literature reviews
Lymphocytes
Metabolism
Pandemics
Pharmacogenetics
Pharmacogenomics
Pneumonia
Polymorphism
Precision medicine
Review
RNA polymerase
sars-cov2
Serology
Severe acute respiratory syndrome coronavirus 2
Single-nucleotide polymorphism
Therapeutic targets
Viruses
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Summary:The latest developments in precision medicine allow the modulation of therapeutic approaches in different pathologies on the basis of the specific molecular characterization of the patient. This review of the literature coupled with in silico analysis was to provide a selected screening of interactions between single-nucleotide polymorphisms (SNPs) and drugs (repurposed, investigational, and biological agents) showing efficacy and toxicityin counteracting Covid-19 infection. In silico analysis of genetic variants related to each drug was performed on such databases as PharmGKB, Ensembl Genome Browser, www.drugs.com, and SNPedia, with an extensive literature review of papers (to May 10, 2020) on Covid-19 treatments using Medline, Embase, International Pharmaceutical Abstracts, PharmGKB, and Google Scholar. The clinical relevance of SNPs, known as both drug targets and markers, considering genetic variations with known drug responses, and the therapeutic consequences are discussed. In the context of clinical treatment of Covid-19, including infection prevention, control measures, and supportive care, this review highlights the importance of a personalized approach in the final selection of therapy, which is probably essential in the management of the Covid-19 pandemic.
ISSN:1178-7066
1178-7066
DOI:10.2147/PGPM.S270069