Naturally occurring anti-P1 with high thermal amplitude complicating ABO blood grouping

Anti-P1 is immunoglobulin M type and occurs naturally; it is often detected as a weak- and cold-reactive antibody. However, in rare cases, it is reactive at 37°C or shows hemolytic transfusion reactions. The presence of high thermal amplitude of anti-P1 cannot be ignored and requires cross-match com...

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Bibliographic Details
Published in:Asian journal of transfusion science 2024-01, Vol.18 (1), p.135-137
Main Authors: Ferdowsi, Shirin, Mohammadi, Saeed, Ahmadnezhad, Moharram, Herfat, Fahimeh, Rezvani, Azita, Eshghi, Peyman, Oodi, Arezoo
Format: Article
Language:English
Subjects:
blood group discrepancy
cold antibody
high thermal amplitude
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Summary:Anti-P1 is immunoglobulin M type and occurs naturally; it is often detected as a weak- and cold-reactive antibody. However, in rare cases, it is reactive at 37°C or shows hemolytic transfusion reactions. The presence of high thermal amplitude of anti-P1 cannot be ignored and requires cross-match compatible red blood cells for transfusion. In the present study, we report three cases with ABO discrepancy due to anti-P1 that was identified as a cold-reacting antibody with high thermal amplitude.
ISSN:0973-6247
1998-3565
DOI:10.4103/ajts.ajts_12_21