Association of circulating biomarkers with illness severity measures differentiates myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 condition: a prospective pilot cohort study

Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID. However, there is limited knowledge regarding their potential association with circulating biomar...

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Bibliographic Details
Published in:Journal of translational medicine 2024-04, Vol.22 (1), p.343-343, Article 343
Main Authors: Domingo, Joan Carles, Battistini, Federica, Cordobilla, Begoña, Zaragozá, Maria Cleofé, Sanmartin-Sentañes, Ramón, Alegre-Martin, Jose, Cambras, Trinitat, Castro-Marrero, Jesus
Format: Article
Language:English
Subjects:
Biomarkers
Chronic fatigue syndrome
Cohort analysis
Cohort Studies
COVID-19
Cross-Sectional Studies
E-selectin
Encephalomyelitis
Endothelial dysfunction
Fatigue
Fatigue Syndrome, Chronic - epidemiology
Females
Hemodynamics
Hospitals
Humans
Illnesses
Infections
Inflammation
Interleukins
IP-10 protein
Leptin
Long COVID
Myalgic encephalomyelitis
Nitrites
Nitrogen dioxide
Patient Acuity
Pilot Projects
Population studies
Post-Acute COVID-19 Syndrome
Principal components analysis
Prospective Studies
Self report
Severe acute respiratory syndrome coronavirus 2
Tachycardia
Tumor necrosis factor-α
Vascular cell adhesion molecule 1
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Summary:Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID. However, there is limited knowledge regarding their potential association with circulating biomarkers and illness severity in these conditions. This single-site, prospective, cross-sectional, pilot cohort study aimed to distinguish between the two patient populations by using self-reported outcome measures and circulating biomarkers of endothelial function and systemic inflammation status. Thirty-one individuals with ME/CFS, 23 individuals with long COVID, and 31 matched sedentary healthy controls were included. All study participants underwent non-invasive cardiovascular hemodynamic challenge testing (10 min NASA lean test) for assessment of orthostatic intolerance. Regression analysis was used to examine associations between outcome measures and circulating biomarkers in the study participants. Classification across groups was based on principal component and discriminant analyses. Four ME/CFS patients (13%), 1 with long COVID (4%), and 1 healthy control (3%) presented postural orthostatic tachycardia syndrome (POTS) using the 10-min NASA lean test. Compared with matched healthy controls, ME/CFS and long COVID subjects showed higher levels of ET-1 (p 
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-024-05148-0