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Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population
Prior knowledge of allele frequencies of cytochrome P450 polymorphisms in a population is crucial for the revision and optimization of existing medication choices and doses. In the current study, the frequency of the CYP2C9*2 , CYP2C9*3 , CYP2C19*2 , CYP2C19*3 , CYP2C19*6 , CYP2C19*17 , and CYP3A4 (...
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| Published in: | Scientific reports 2021-06, Vol.11 (1), p.12343-12343, Article 12343 |
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| creator | Sukprasong, Rattanaporn Chuwongwattana, Sumonrat Koomdee, Napatrupron Jantararoungtong, Thawinee Prommas, Santirhat Jinda, Pimonpan Rachanakul, Jiratha Nuntharadthanaphong, Nutthan Jongjitsook, Nutcha Puangpetch, Apichaya Sukasem, Chonlaphat |
| description | Prior knowledge of allele frequencies of cytochrome P450 polymorphisms in a population is crucial for the revision and optimization of existing medication choices and doses. In the current study, the frequency of the
CYP2C9*2
,
CYP2C9*3
,
CYP2C19*2
,
CYP2C19*3
,
CYP2C19*6
,
CYP2C19*17
, and
CYP3A4
(rs4646437) alleles in a Thai population across different regions of Thailand was examined. Tests for polymorphisms of
CYP2C9
and
CYP3A4
were performed using TaqMan SNP genotyping assay and
CYP2C19
was performed using two different methods; TaqMan SNP genotyping assay and Luminex x Tag V3. The blood samples were collected from 1205 unrelated healthy individuals across different regions within Thailand. Polymorphisms of
CYP2C9
and
CYP2C19
were transformed into phenotypes, which included normal metabolizer (NM), intermediate metabolizer (IM), poor metabolizer (PM), and rapid metabolizers (RM). The
CYP2C9
allele frequencies among the Thai population were 0.08% and 5.27% for the
CYP2C9*2
and
CYP2C9*3
alleles, respectively. The
CYP2C19
allele frequencies among the Thai population were 25.60%, 2.50%, 0.10%, and 1.80% for the
CYP2C19*2
,
CYP2C19*3
,
CYP2C19*6
, and
CYP2C19*17
alleles, respectively. The allele frequency of the
CYP3A4
(rs4646437) variant allele was 28.50% in the Thai population. The frequency of the
CYP2C9*3
allele was significantly lower among the Northern Thai population (P |
| doi_str_mv | 10.1038/s41598-021-90969-y |
| format | article |
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CYP2C9*2
,
CYP2C9*3
,
CYP2C19*2
,
CYP2C19*3
,
CYP2C19*6
,
CYP2C19*17
, and
CYP3A4
(rs4646437) alleles in a Thai population across different regions of Thailand was examined. Tests for polymorphisms of
CYP2C9
and
CYP3A4
were performed using TaqMan SNP genotyping assay and
CYP2C19
was performed using two different methods; TaqMan SNP genotyping assay and Luminex x Tag V3. The blood samples were collected from 1205 unrelated healthy individuals across different regions within Thailand. Polymorphisms of
CYP2C9
and
CYP2C19
were transformed into phenotypes, which included normal metabolizer (NM), intermediate metabolizer (IM), poor metabolizer (PM), and rapid metabolizers (RM). The
CYP2C9
allele frequencies among the Thai population were 0.08% and 5.27% for the
CYP2C9*2
and
CYP2C9*3
alleles, respectively. The
CYP2C19
allele frequencies among the Thai population were 25.60%, 2.50%, 0.10%, and 1.80% for the
CYP2C19*2
,
CYP2C19*3
,
CYP2C19*6
, and
CYP2C19*17
alleles, respectively. The allele frequency of the
CYP3A4
(rs4646437) variant allele was 28.50% in the Thai population. The frequency of the
CYP2C9*3
allele was significantly lower among the Northern Thai population (P < 0.001). The frequency of the
CYP2C19*17
allele was significantly higher in the Southern Thai population (P < 0.001). Our results may provide an understanding of the ethnic differences in drug responses and support for the utilization of pharmacogenomics testing in clinical practice.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-021-90969-y</identifier><identifier>PMID: 34117307</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208 ; 692/308 ; 692/4017 ; Alleles ; Cytochrome P450 ; Gene frequency ; Genotyping ; Humanities and Social Sciences ; multidisciplinary ; Pharmacogenomics ; Phenotypes ; Population ; Population genetics ; Science ; Science (multidisciplinary) ; Single-nucleotide polymorphism</subject><ispartof>Scientific reports, 2021-06, Vol.11 (1), p.12343-12343, Article 12343</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-63de77b8619a283c5f586b06dbba2e7bc99a5a6545501f50696a706794e040473</citedby><cites>FETCH-LOGICAL-c570t-63de77b8619a283c5f586b06dbba2e7bc99a5a6545501f50696a706794e040473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2540000290/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2540000290?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids></links><search><creatorcontrib>Sukprasong, Rattanaporn</creatorcontrib><creatorcontrib>Chuwongwattana, Sumonrat</creatorcontrib><creatorcontrib>Koomdee, Napatrupron</creatorcontrib><creatorcontrib>Jantararoungtong, Thawinee</creatorcontrib><creatorcontrib>Prommas, Santirhat</creatorcontrib><creatorcontrib>Jinda, Pimonpan</creatorcontrib><creatorcontrib>Rachanakul, Jiratha</creatorcontrib><creatorcontrib>Nuntharadthanaphong, Nutthan</creatorcontrib><creatorcontrib>Jongjitsook, Nutcha</creatorcontrib><creatorcontrib>Puangpetch, Apichaya</creatorcontrib><creatorcontrib>Sukasem, Chonlaphat</creatorcontrib><title>Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><description>Prior knowledge of allele frequencies of cytochrome P450 polymorphisms in a population is crucial for the revision and optimization of existing medication choices and doses. In the current study, the frequency of the
CYP2C9*2
,
CYP2C9*3
,
CYP2C19*2
,
CYP2C19*3
,
CYP2C19*6
,
CYP2C19*17
, and
CYP3A4
(rs4646437) alleles in a Thai population across different regions of Thailand was examined. Tests for polymorphisms of
CYP2C9
and
CYP3A4
were performed using TaqMan SNP genotyping assay and
CYP2C19
was performed using two different methods; TaqMan SNP genotyping assay and Luminex x Tag V3. The blood samples were collected from 1205 unrelated healthy individuals across different regions within Thailand. Polymorphisms of
CYP2C9
and
CYP2C19
were transformed into phenotypes, which included normal metabolizer (NM), intermediate metabolizer (IM), poor metabolizer (PM), and rapid metabolizers (RM). The
CYP2C9
allele frequencies among the Thai population were 0.08% and 5.27% for the
CYP2C9*2
and
CYP2C9*3
alleles, respectively. The
CYP2C19
allele frequencies among the Thai population were 25.60%, 2.50%, 0.10%, and 1.80% for the
CYP2C19*2
,
CYP2C19*3
,
CYP2C19*6
, and
CYP2C19*17
alleles, respectively. The allele frequency of the
CYP3A4
(rs4646437) variant allele was 28.50% in the Thai population. The frequency of the
CYP2C9*3
allele was significantly lower among the Northern Thai population (P < 0.001). The frequency of the
CYP2C19*17
allele was significantly higher in the Southern Thai population (P < 0.001). Our results may provide an understanding of the ethnic differences in drug responses and support for the utilization of pharmacogenomics testing in clinical practice.</description><subject>631/208</subject><subject>692/308</subject><subject>692/4017</subject><subject>Alleles</subject><subject>Cytochrome P450</subject><subject>Gene frequency</subject><subject>Genotyping</subject><subject>Humanities and Social Sciences</subject><subject>multidisciplinary</subject><subject>Pharmacogenomics</subject><subject>Phenotypes</subject><subject>Population</subject><subject>Population genetics</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Single-nucleotide polymorphism</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9ks1u1DAQxyMEolXpC3CKxIUDAdvxR3xBWq2grVQJDuXAyXKcya5Xjh3spFL6JDwu3k0FlANzmfH4Pz-PxlMUrzF6j1HdfEgUM9lUiOBKIslltTwrzgmirCI1Ic__is-Ky5QOKBsjkmL5sjirKcaiRuK8-LlxDhyUfYQfM3hjIZWhL5P1u5z1s3EQJttBOQa3DCGOe5uGk8Q4663Rzi2lHcYQJ-2nsovzrhpg0m1w9iFDSvAPy5Ch2-9fyVa-Wz3Ogfbd8VBvaGl9qcu7vbb5lXF2erLBvype9NoluHz0F8W3z5_uttfV7Zerm-3mtjJMoKnidQdCtA3HUpOmNqxnDW8R79pWExCtkVIzzRllDOGeIS65FogLSQFRREV9Udys3C7ogxqjHXRcVNBWnRIh7pSOk81zUIK2puWC1QxRinijNZYCA6EMQQtEZtbHlTXO7QCdAT9F7Z5An954u1e7cK8aLPNn8gx4-wiIIX9HmtRgkwHntIcwJ0UYRQxzLI59v_lHeghz9HlUJ1U2IlFWkVVlYkgpQv-7GYzUcY_Uukcq75E67ZFaclG9FqUs9juIf9D_qfoFviLJdg</recordid><startdate>20210611</startdate><enddate>20210611</enddate><creator>Sukprasong, Rattanaporn</creator><creator>Chuwongwattana, 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population</title><author>Sukprasong, Rattanaporn ; Chuwongwattana, Sumonrat ; Koomdee, Napatrupron ; Jantararoungtong, Thawinee ; Prommas, Santirhat ; Jinda, Pimonpan ; Rachanakul, Jiratha ; Nuntharadthanaphong, Nutthan ; Jongjitsook, Nutcha ; Puangpetch, Apichaya ; Sukasem, Chonlaphat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-63de77b8619a283c5f586b06dbba2e7bc99a5a6545501f50696a706794e040473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>631/208</topic><topic>692/308</topic><topic>692/4017</topic><topic>Alleles</topic><topic>Cytochrome P450</topic><topic>Gene frequency</topic><topic>Genotyping</topic><topic>Humanities and Social Sciences</topic><topic>multidisciplinary</topic><topic>Pharmacogenomics</topic><topic>Phenotypes</topic><topic>Population</topic><topic>Population genetics</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sukprasong, Rattanaporn</creatorcontrib><creatorcontrib>Chuwongwattana, Sumonrat</creatorcontrib><creatorcontrib>Koomdee, Napatrupron</creatorcontrib><creatorcontrib>Jantararoungtong, Thawinee</creatorcontrib><creatorcontrib>Prommas, Santirhat</creatorcontrib><creatorcontrib>Jinda, Pimonpan</creatorcontrib><creatorcontrib>Rachanakul, Jiratha</creatorcontrib><creatorcontrib>Nuntharadthanaphong, Nutthan</creatorcontrib><creatorcontrib>Jongjitsook, Nutcha</creatorcontrib><creatorcontrib>Puangpetch, Apichaya</creatorcontrib><creatorcontrib>Sukasem, Chonlaphat</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sukprasong, Rattanaporn</au><au>Chuwongwattana, Sumonrat</au><au>Koomdee, Napatrupron</au><au>Jantararoungtong, Thawinee</au><au>Prommas, Santirhat</au><au>Jinda, Pimonpan</au><au>Rachanakul, Jiratha</au><au>Nuntharadthanaphong, Nutthan</au><au>Jongjitsook, Nutcha</au><au>Puangpetch, Apichaya</au><au>Sukasem, Chonlaphat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><date>2021-06-11</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>12343</spage><epage>12343</epage><pages>12343-12343</pages><artnum>12343</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Prior knowledge of allele frequencies of cytochrome P450 polymorphisms in a population is crucial for the revision and optimization of existing medication choices and doses. In the current study, the frequency of the
CYP2C9*2
,
CYP2C9*3
,
CYP2C19*2
,
CYP2C19*3
,
CYP2C19*6
,
CYP2C19*17
, and
CYP3A4
(rs4646437) alleles in a Thai population across different regions of Thailand was examined. Tests for polymorphisms of
CYP2C9
and
CYP3A4
were performed using TaqMan SNP genotyping assay and
CYP2C19
was performed using two different methods; TaqMan SNP genotyping assay and Luminex x Tag V3. The blood samples were collected from 1205 unrelated healthy individuals across different regions within Thailand. Polymorphisms of
CYP2C9
and
CYP2C19
were transformed into phenotypes, which included normal metabolizer (NM), intermediate metabolizer (IM), poor metabolizer (PM), and rapid metabolizers (RM). The
CYP2C9
allele frequencies among the Thai population were 0.08% and 5.27% for the
CYP2C9*2
and
CYP2C9*3
alleles, respectively. The
CYP2C19
allele frequencies among the Thai population were 25.60%, 2.50%, 0.10%, and 1.80% for the
CYP2C19*2
,
CYP2C19*3
,
CYP2C19*6
, and
CYP2C19*17
alleles, respectively. The allele frequency of the
CYP3A4
(rs4646437) variant allele was 28.50% in the Thai population. The frequency of the
CYP2C9*3
allele was significantly lower among the Northern Thai population (P < 0.001). The frequency of the
CYP2C19*17
allele was significantly higher in the Southern Thai population (P < 0.001). Our results may provide an understanding of the ethnic differences in drug responses and support for the utilization of pharmacogenomics testing in clinical practice.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34117307</pmid><doi>10.1038/s41598-021-90969-y</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Scientific reports, 2021-06, Vol.11 (1), p.12343-12343, Article 12343 |
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| language | eng |
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| source | Publicly Available Content Database; PubMed Central; Free Full-Text Journals in Chemistry; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 631/208 692/308 692/4017 Alleles Cytochrome P450 Gene frequency Genotyping Humanities and Social Sciences multidisciplinary Pharmacogenomics Phenotypes Population Population genetics Science Science (multidisciplinary) Single-nucleotide polymorphism |
| title | Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T10%3A54%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Allele%20frequencies%20of%20single%20nucleotide%20polymorphisms%20of%20clinically%20important%20drug-metabolizing%20enzymes%20CYP2C9,%20CYP2C19,%20and%20CYP3A4%20in%20a%20Thai%20population&rft.jtitle=Scientific%20reports&rft.au=Sukprasong,%20Rattanaporn&rft.date=2021-06-11&rft.volume=11&rft.issue=1&rft.spage=12343&rft.epage=12343&rft.pages=12343-12343&rft.artnum=12343&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-021-90969-y&rft_dat=%3Cproquest_doaj_%3E2540516177%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c570t-63de77b8619a283c5f586b06dbba2e7bc99a5a6545501f50696a706794e040473%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2540000290&rft_id=info:pmid/34117307&rfr_iscdi=true |