P139 The FaMaLE study: investigating failing maternal-fetal tolerance in pregnant women with SLE

ObjectivePregnant women with systemic lupus erythematosus (SLE) have an increased risk of maternal complications and adverse fetal outcomes, like preeclampsia, preterm birth and fetal growth restriction. Interestingly, this increased risk persists in subsequent pregnancies, whereas it decreases in h...

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Bibliographic Details
Published in:Lupus science & medicine 2024-03, Vol.11 (Suppl 1), p.A145-A145
Main Authors: Dankers, Wendy, Parra Sanchez, A, Veeneman, K, O’Byrne, AM, Germe, SA, Gaal, MFHM van, Ruitenbeek, JF, de Boer, M, van Baarsen, LGM, Bultink, IEM
Format: Article
Language:English
Subjects:
Flow cytometry
Placenta
Poster Presentations
Preeclampsia
Pregnancy complications
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Summary:ObjectivePregnant women with systemic lupus erythematosus (SLE) have an increased risk of maternal complications and adverse fetal outcomes, like preeclampsia, preterm birth and fetal growth restriction. Interestingly, this increased risk persists in subsequent pregnancies, whereas it decreases in healthy women due to the development of maternal-fetal tolerance. Since maternal-fetal tolerance is crucial for a healthy pregnancy, we hypothesize that its failure contributes to the increased risk of pregnancy complications in women with SLE. Therefore, we initiated the FaMaLE study to investigate failing maternal-fetal tolerance in pregnant women with SLE.MethodsIn the FaMaLE study, healthy women and women with SLE are included in their first trimester of pregnancy (
ISSN:2053-8790
DOI:10.1136/lupus-2024-el.193