Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects

The association of HTRA1 rs11200638 and ARMS2 rs10490924 gene polymorphisms with response to intravitreal ranibizumab therapy among neovascular AMD (nAMD) subjects in Malaysia was determined in this study, followed by the expression of HTRA1 and ARMS2 genes. Both single nucleotide polymorphisms (SNP...

Full description

Saved in:
Bibliographic Details
Published in:Human genomics 2019-02, Vol.13 (1), p.13-12, Article 13
Main Authors: Mohamad, Nur Afiqah, Ramachandran, Vasudevan, Mohd Isa, Hazlita, Chan, Yoke Mun, Ngah, Nor Fariza, Ching, Siew Mooi, Hoo, Fan Kee, Wan Sulaiman, Wan Aliaa, Inche Mat, Liyana Najwa, Mohamed, Mohd Hazmi
Format: Article
Language:English
Subjects:
Age
Age-related macular degeneration
Age-related maculopathy susceptibility 2
Aged
Angiogenesis
Angiogenesis Inhibitors - therapeutic use
Female
Gene Expression - drug effects
Genes
High temperature requirement a serine peptidase 1
High-Temperature Requirement A Serine Peptidase 1 - genetics
Homozygote
Humans
Immunotherapy
Influence
Macular degeneration
Macular Degeneration - drug therapy
Macular Degeneration - genetics
Male
Middle Aged
Mitochondria
Mitochondrial DNA
Monoclonal antibodies
mRNA
Polymorphism
Polymorphism, Single Nucleotide
Primary Research
Prospective Studies
Proteins - genetics
Ranibizumab
Ranibizumab - therapeutic use
Retina
Single-nucleotide polymorphism
Studies
Treatment Outcome
Vascular endothelial growth factor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The association of HTRA1 rs11200638 and ARMS2 rs10490924 gene polymorphisms with response to intravitreal ranibizumab therapy among neovascular AMD (nAMD) subjects in Malaysia was determined in this study, followed by the expression of HTRA1 and ARMS2 genes. Both single nucleotide polymorphisms (SNPs) recorded a significant association between nAMD and controls with HTRA1 rs11200638 at P = 0.018 (OR = 1.52, 95% CI = 1.07-215) and ARMS2 rs10490924 at P 
ISSN:1479-7364
1473-9542
1479-7364
DOI:10.1186/s40246-019-0197-3