Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes

Streptococcus pyogenes (group A Streptococcus [GAS]) is a major human pathogen that causes a wide spectrum of clinical manifestations. Although invasive GAS (iGAS) infections are relatively uncommon, emm3/ST15 GAS is a highly virulent, invasive, and pathogenic strain. Global molecular epidemiology a...

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Published in:BMC infectious diseases 2017-12, Vol.17 (1), p.774-774, Article 774
Main Authors: Sekizuka, Tsuyoshi, Nai, Emina, Yoshida, Tomohiro, Endo, Shota, Hamajima, Emi, Akiyama, Satoka, Ikuta, Yoji, Obana, Natsuko, Kawaguchi, Takahiro, Hayashi, Kenta, Noda, Masahiro, Sumita, Tomoko, Kokaji, Masayuki, Katori, Tatsuo, Hashino, Masanori, Oba, Kunihiro, Kuroda, Makoto
Format: Article
Language:English
Subjects:
Analysis
Care and treatment
Case Report
CAT scans
Diagnosis
emm3
Health aspects
Immunoglobulins
Invasive
ST15
Streptococcus pyogenes
Toxic shock syndrome
Whole-genome sequencing
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Summary:Streptococcus pyogenes (group A Streptococcus [GAS]) is a major human pathogen that causes a wide spectrum of clinical manifestations. Although invasive GAS (iGAS) infections are relatively uncommon, emm3/ST15 GAS is a highly virulent, invasive, and pathogenic strain. Global molecular epidemiology analysis has suggested that the frequency of emm3 GAS has been recently increasing. A 14-year-old patient was diagnosed with streptococcal toxic shock syndrome and severe pneumonia, impaired renal function, and rhabdomyolysis. GAS was isolated from a culture of endotracheal aspirates and designated as KS030. Comparative genome analysis suggested that KS030 is classified as emm3 (emm-type) and ST15 (multilocus sequencing typing [MLST]), which is similar to iGAS isolates identified in the UK (2013) and Switzerland (2015). We conclude that the global dissemination of emm3/ST15 GAS strain has the potential to cause invasive disease.
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-017-2870-2