Basic patient characteristics predict antimicrobial resistance in E. coli from urinary tract specimens: a retrospective cohort analysis of 5246 urine samples

Antimicrobial resistance data from surveillance networks are frequently do not accurately predict resistance patterns of urinary tract infections at the bedside. To determine simple patient- and institution-related risk factors affecting antimicrobial resistance patterns of Escherichia coli urine is...

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Bibliographic Details
Published in:Swiss medical weekly 2018-11, Vol.148 (4546), p.w14660-w14660
Main Authors: Erb, Stefan, Frei, Reno, Tschudin Sutter, Sarah, Egli, Adrian, Dangel, Marc, Bonkat, Gernot, Widmer, Andreas F
Format: Article
Language:English
Subjects:
Age Factors
Amoxicillin - pharmacology
Anti-Bacterial Agents - pharmacology
antimicrobial resistance
Catheters, Indwelling - statistics & numerical data
ciprofloxacin
Ciprofloxacin - pharmacology
cotrimoxazole
Drug Resistance, Bacterial
Escherichia coli - drug effects
Escherichia coli - isolation & purification
Escherichia coli Infections - drug therapy
Escherichia coli Infections - microbiology
Female
Hospitals
Humans
Male
Middle Aged
Retrospective Studies
risk factors
Sex Factors
Switzerland
Trimethoprim, Sulfamethoxazole Drug Combination - pharmacology
Urinary Tract Infections - drug therapy
Urinary Tract Infections - microbiology
Urine
urology
Urology Department, Hospital - statistics & numerical data
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Summary:Antimicrobial resistance data from surveillance networks are frequently do not accurately predict resistance patterns of urinary tract infections at the bedside. To determine simple patient- and institution-related risk factors affecting antimicrobial resistance patterns of Escherichia coli urine isolates. From January 2012 to May 2015 all consecutive urine samples with significant growth of E. coli (≥103 CFU/ml) obtained from a tertiary care hospital were analysed for antimicrobial susceptibility and related to basic clinical data such a patient age, ward, sample type (catheter vs non-catheter urine). Antimicrobial susceptibility testing was available for 5246 E. coli urine isolates from 4870 patients. E. coli was most commonly resistant to amoxicillin (43.1%), cotrimoxazole (24.5%) and ciprofloxacin (17.4%). Resistance rates were low for meropenem (0.0%), fosfomycin (0.9%) and nitrofurantoin (1.5%). Significantly higher rates of resistance to ciprofloxacin (32.8 vs 15.8%) and cotrimoxazole (30.6 vs 23.9%) were found in urological patients compared with patients on other wards (p
ISSN:1424-3997
1424-3997
DOI:10.4414/smw.2018.14660