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Longitudinal change in ventricular volume is accelerated in astronauts undergoing long-duration spaceflight
An 11–25% increase in total ventricular volume has been documented in astronauts following spaceflight on the ISS. Given the approximately 2-year time interval between pre- and post-flight MRI, it is unknown if ventricular enlargement simply reflects normal aging or is unique to spaceflight exposure...
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| Published in: | Aging brain 2021-01, Vol.1, p.100017-100017, Article 100017 |
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| container_title | Aging brain |
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| creator | Roberts, Donna R. Inglesby, Dani C. Brown, Truman R. Collins, Heather R. Eckert, Mark A. Asemani, Davud |
| description | An 11–25% increase in total ventricular volume has been documented in astronauts following spaceflight on the ISS. Given the approximately 2-year time interval between pre- and post-flight MRI, it is unknown if ventricular enlargement simply reflects normal aging or is unique to spaceflight exposure. Therefore, we compared percent ventricular volume change per year (PVVC/yr) documented on pre- to post-flight MRI in a group of NASA ISS astronauts (n = 18, 16.7% women, mean age (SD) 48.43 (4.35) years) with two groups who underwent longitudinal MRI: (1.) healthy age- and sex-matched adults (n = 18, 16.7% women, mean age (SD) 51.26 (3.88) years), and (2.) healthy older adults (n = 79, 16.5% women, mean age (SD) 73.26 (5.34) years). The astronauts, who underwent a mean (SD) 173.4 (51.3) days in spaceflight, showed a greater increase in PVVC/yr than the control (6.86 vs 2.23%, respectively, p |
| doi_str_mv | 10.1016/j.nbas.2021.100017 |
| format | article |
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NASA astronauts who were exposed to prolonged spaceflight experienced an annual rate of ventricular expansion more than three times that expected from normal aging.</description><identifier>ISSN: 2589-9589</identifier><identifier>EISSN: 2589-9589</identifier><identifier>DOI: 10.1016/j.nbas.2021.100017</identifier><identifier>PMID: 36911514</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Cerebral ventricles ; Normal aging ; Spaceflight</subject><ispartof>Aging brain, 2021-01, Vol.1, p.100017-100017, Article 100017</ispartof><rights>2021 The Author(s)</rights><rights>2021 The Author(s).</rights><rights>2021 The Author(s) 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-4bc5c61080f2c57345fb79270f5e7b74c8964753a692b3dec628f243d024ccc43</citedby><cites>FETCH-LOGICAL-c451t-4bc5c61080f2c57345fb79270f5e7b74c8964753a692b3dec628f243d024ccc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997154/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S258995892100013X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3547,27923,27924,45779,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36911514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roberts, Donna R.</creatorcontrib><creatorcontrib>Inglesby, Dani C.</creatorcontrib><creatorcontrib>Brown, Truman R.</creatorcontrib><creatorcontrib>Collins, Heather R.</creatorcontrib><creatorcontrib>Eckert, Mark A.</creatorcontrib><creatorcontrib>Asemani, Davud</creatorcontrib><title>Longitudinal change in ventricular volume is accelerated in astronauts undergoing long-duration spaceflight</title><title>Aging brain</title><addtitle>Aging Brain</addtitle><description>An 11–25% increase in total ventricular volume has been documented in astronauts following spaceflight on the ISS. Given the approximately 2-year time interval between pre- and post-flight MRI, it is unknown if ventricular enlargement simply reflects normal aging or is unique to spaceflight exposure. Therefore, we compared percent ventricular volume change per year (PVVC/yr) documented on pre- to post-flight MRI in a group of NASA ISS astronauts (n = 18, 16.7% women, mean age (SD) 48.43 (4.35) years) with two groups who underwent longitudinal MRI: (1.) healthy age- and sex-matched adults (n = 18, 16.7% women, mean age (SD) 51.26 (3.88) years), and (2.) healthy older adults (n = 79, 16.5% women, mean age (SD) 73.26 (5.34) years). The astronauts, who underwent a mean (SD) 173.4 (51.3) days in spaceflight, showed a greater increase in PVVC/yr than the control (6.86 vs 2.23%, respectively, p < .001) and older adult (4.18%, p = 0.04) groups. These results highlight that on top of physiologically ventricular volume changes due to normal aging, NASA astronauts undergoing ISS missions experience an additional 4.63% PVVC/yr and underscore the need to perform post-flight follow-up scans to determine the time course of PVVC in astronauts over time back on Earth along with monitoring to determine if the PVVC is ultimately clinically relevant.
NASA astronauts who were exposed to prolonged spaceflight experienced an annual rate of ventricular expansion more than three times that expected from normal aging.</description><subject>Cerebral ventricles</subject><subject>Normal aging</subject><subject>Spaceflight</subject><issn>2589-9589</issn><issn>2589-9589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kU9v1DAQxSMEolXpF-CAcuSyW_9PLCEkVAGttBIXOFuOPcl68dqL7azEt8chpWovXGxr_OY3o_ea5i1GW4ywuDlsw6DzliCCawEh3L1oLgnv5UbW4-WT90VznfOhSgjHlGL8urmgQmLMMbtsfu5imFyZrQvat2avwwStC-0ZQknOzF6n9hz9fKzV3GpjwEPSBewi0rmkGPRccjsHC2mKLkytr8SNnavKxdDmkzYwejfty5vm1ah9huuH-6r58eXz99u7ze7b1_vbT7uNYRyXDRsMNwKjHo3E8I4yPg6dJB0aOXRDx0wvBes41UKSgVowgvQjYdQiwowxjF419yvXRn1Qp-SOOv1WUTv1txDTpHQqznhQnWADoxpzwTUTjEkrK8aykQnJOMWV9XFlnebhCNYstmj_DPr8J7i9muJZSSk7zJdl3j8AUvw1Qy7q6HJ10esAcc6KdL2oSUguq5SsUpNizgnGxzEYqSV0dVBL6GoJXa2h16Z3Txd8bPkXcRV8WAVQLT87SCobB8GAdQlMqZ64__H_AGnIvwA</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Roberts, Donna R.</creator><creator>Inglesby, Dani C.</creator><creator>Brown, Truman R.</creator><creator>Collins, Heather R.</creator><creator>Eckert, Mark A.</creator><creator>Asemani, Davud</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20210101</creationdate><title>Longitudinal change in ventricular volume is accelerated in astronauts undergoing long-duration spaceflight</title><author>Roberts, Donna R. ; Inglesby, Dani C. ; Brown, Truman R. ; Collins, Heather R. ; Eckert, Mark A. ; Asemani, Davud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-4bc5c61080f2c57345fb79270f5e7b74c8964753a692b3dec628f243d024ccc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cerebral ventricles</topic><topic>Normal aging</topic><topic>Spaceflight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roberts, Donna R.</creatorcontrib><creatorcontrib>Inglesby, Dani C.</creatorcontrib><creatorcontrib>Brown, Truman R.</creatorcontrib><creatorcontrib>Collins, Heather R.</creatorcontrib><creatorcontrib>Eckert, Mark A.</creatorcontrib><creatorcontrib>Asemani, Davud</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Aging brain</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roberts, Donna R.</au><au>Inglesby, Dani C.</au><au>Brown, Truman R.</au><au>Collins, Heather R.</au><au>Eckert, Mark A.</au><au>Asemani, Davud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal change in ventricular volume is accelerated in astronauts undergoing long-duration spaceflight</atitle><jtitle>Aging brain</jtitle><addtitle>Aging Brain</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>1</volume><spage>100017</spage><epage>100017</epage><pages>100017-100017</pages><artnum>100017</artnum><issn>2589-9589</issn><eissn>2589-9589</eissn><abstract>An 11–25% increase in total ventricular volume has been documented in astronauts following spaceflight on the ISS. Given the approximately 2-year time interval between pre- and post-flight MRI, it is unknown if ventricular enlargement simply reflects normal aging or is unique to spaceflight exposure. Therefore, we compared percent ventricular volume change per year (PVVC/yr) documented on pre- to post-flight MRI in a group of NASA ISS astronauts (n = 18, 16.7% women, mean age (SD) 48.43 (4.35) years) with two groups who underwent longitudinal MRI: (1.) healthy age- and sex-matched adults (n = 18, 16.7% women, mean age (SD) 51.26 (3.88) years), and (2.) healthy older adults (n = 79, 16.5% women, mean age (SD) 73.26 (5.34) years). The astronauts, who underwent a mean (SD) 173.4 (51.3) days in spaceflight, showed a greater increase in PVVC/yr than the control (6.86 vs 2.23%, respectively, p < .001) and older adult (4.18%, p = 0.04) groups. These results highlight that on top of physiologically ventricular volume changes due to normal aging, NASA astronauts undergoing ISS missions experience an additional 4.63% PVVC/yr and underscore the need to perform post-flight follow-up scans to determine the time course of PVVC in astronauts over time back on Earth along with monitoring to determine if the PVVC is ultimately clinically relevant.
NASA astronauts who were exposed to prolonged spaceflight experienced an annual rate of ventricular expansion more than three times that expected from normal aging.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>36911514</pmid><doi>10.1016/j.nbas.2021.100017</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elsevier ScienceDirect Journals; PubMed Central |
| subjects | Cerebral ventricles Normal aging Spaceflight |
| title | Longitudinal change in ventricular volume is accelerated in astronauts undergoing long-duration spaceflight |
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