Scientific Evidences of Calorie Restriction and Intermittent Fasting for Neuroprotection in Traumatic Brain Injury Animal Models: A Review of the Literature

It has widely been accepted that food restriction (FR) without malnutrition has multiple health benefits. Various calorie restriction (CR) and intermittent fasting (IF) regimens have recently been reported to exert neuroprotective effects in traumatic brain injury (TBI) through variable mechanisms....

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Bibliographic Details
Published in:Nutrients 2022-03, Vol.14 (7), p.1431
Main Authors: Xu, Yang, Liu, Zejie, Xu, Shuting, Li, Chengxian, Li, Manrui, Cao, Shuqiang, Sun, Yuwen, Dai, Hao, Guo, Yadong, Chen, Xiameng, Liang, Weibo
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animal cognition
Animal models
Animals
Apoptosis
Autophagy
Brain Injuries, Traumatic
Brain research
Caloric Restriction
calorie restriction
Calories
Cell growth
Cognitive ability
Disease Models, Animal
Fasting
Fasting - physiology
Food availability
glial cell responses
Glial cells
Glial plasticity
hippocampal neurogenesis
Hippocampus
intermittent fasting
Literature reviews
Malnutrition
Mitochondria
mitochondrial dysfunction
Neurogenesis
Neuronal-glial interactions
Neuroplasticity
Neuroprotection
Neuroprotective Agents - pharmacology
Nutrient deficiency
Pathogenesis
Review
Traumatic brain injury
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Summary:It has widely been accepted that food restriction (FR) without malnutrition has multiple health benefits. Various calorie restriction (CR) and intermittent fasting (IF) regimens have recently been reported to exert neuroprotective effects in traumatic brain injury (TBI) through variable mechanisms. However, the evidence connecting CR or IF to neuroprotection in TBI as well as current issues remaining in this research field have yet to be reviewed in literature. The objective of our review was therefore to weigh the evidence that suggests the connection between CR/IF with recovery promotion following TBI. Medline, Google Scholar and Web of Science were searched from inception to 25 February 2022. An overwhelming number of results generated suggest that several types of CR/IF play a promising role in promoting post-TBI recovery. This recovery is believed to be achieved by alleviating mitochondrial dysfunction, promoting hippocampal neurogenesis, inhibiting glial cell responses, shaping neural cell plasticity, as well as targeting apoptosis and autophagy. Further, we represent our views on the current issues and provide thoughts on the future direction of this research field.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14071431