PREDICTIVE FACTORS OF MORBIDITY ASSOCIATED WITH ESOPHAGEAL VARICEAL BLEEDING IN CHILDREN WITH PORTAL HYPERTENSION

•Most data on the natural history of portal hypertension come from studies in adults. •The morbidity rate of upper gastrointestinal bleeding in children with portal hypertension tend to be underestimated. •This study showed the relevance of morbidity rates after variceal hemorrhage in pediatric pati...

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Published in:Arquivos de gastroenterologia 2023-06, Vol.60 (2), p.247-256
Main Authors: Gama, Maria Carolina Feres de Lima Rocha, Fagundes, Eleonora Druve Tavares, Queiroz, Thaís Costa Nascentes, Rodrigues, Adriana Teixeira, Vieira, Luiza Caroline, Ferreira, Alexandre Rodrigues
Format: Article
Language:English
Subjects:
acute variceal bleeding
children
esophageal varices
GASTROENTEROLOGY & HEPATOLOGY
morbidity
Portal hypertension
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Summary:•Most data on the natural history of portal hypertension come from studies in adults. •The morbidity rate of upper gastrointestinal bleeding in children with portal hypertension tend to be underestimated. •This study showed the relevance of morbidity rates after variceal hemorrhage in pediatric patients, especially those with cirrhosis. •Patients with hemodynamic instability requiring blood transfusion or expansion on admission are at increased risk of complications secondary to upper gastrointestinal bleeding and should be closely monitored. Background - Most data on the natural history of portal hypertension come from studies in adults. The morbidity rate of upper gastrointestinal bleeding (UGIB) in children with portal hypertension has not been systematically characterized. Objective - To describe the morbidity and mortality of UGIB in pediatric patients with portal hypertension and identify predictive factors for the occurrence of its main complications. Methods - This retrospective study included pediatric patients with cirrhotic portal hypertension or with extrahepatic portal vein obstruction (EHPVO). Mortality and UGIB complications within a period of up to 6 weeks of the bleeding were investigated. To determine the predictive factors of morbidity, a multivariate analysis was performed using logistic regression; all results were considered significant at P
ISSN:0004-2803
1678-4219
1678-4219
DOI:10.1590/S0004-2803.202302023-37