Preparation of Paclitaxel-Encapsulated Bio-Functionalized Selenium Nanoparticles and Evaluation of Their Efficacy against Cervical Cancer

The potentiality of nanomedicine in the cancer treatment being widely recognized in the recent years. In the present investigation, the synergistic effects of chitosan-modified selenium nanoparticles loaded with paclitaxel (PTX-chit-SeNPs) were studied. These selenium nanoparticles were tested for d...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-10, Vol.27 (21), p.7290
Main Authors: Menon, Soumya, Jayakodi, Santhoshkumar, Yadav, Kanti Kusum, Somu, Prathap, Isaq, Mona, Shanmugam, Venkat Kumar, Chaitanyakumar, Amballa, Basavegowda, Nagaraj
Format: Article
Language:English
Subjects:
anticancer
Apoptosis
Biocompatibility
Cancer
Cancer therapies
Care and treatment
Cell culture
Cell cycle
Cervical cancer
Cervix
Chitosan
Diagnosis
Drug therapy
Efficiency
Encapsulation
Enzymes
flow cytometer
Gene expression
Mucuna pruriens seed extract
Nanoparticles
Nanotechnology
Oxidative stress
Paclitaxel
Physiology
Phytochemicals
Reagents
Seeds
Selenium
selenium nanoparticles
Spectrum analysis
Synergistic effect
Zeta potential
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Summary:The potentiality of nanomedicine in the cancer treatment being widely recognized in the recent years. In the present investigation, the synergistic effects of chitosan-modified selenium nanoparticles loaded with paclitaxel (PTX-chit-SeNPs) were studied. These selenium nanoparticles were tested for drug release analysis at a pH of 7.4 and 5.5, and further characterized using FTIR, DLS, zeta potential, and TEM to confirm their morphology, and the encapsulation of the drug was carried out using UPLC analysis. Quantitative evaluation of anti-cancer properties was performed via MTT analysis, apoptosis, gene expression analysis, cell cycle arrest, and over-production of ROS. The unique combination of phytochemicals from the seed extract, chitosan, paclitaxel, and selenium nanoparticles can be effectively utilized to combat cancerous cells. The production of the nanosystem has been demonstrated to be cost-effective and have unique characteristics, and can be utilized for improving future diagnostic approaches.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27217290