Treatment Efficacy and Compliance in Patients with Diabetic Macular Edema Treated with Ranibizumab in a Real-Life Setting

Purpose. To assess real-life efficacy of ranibizumab and treatment compliance of patients with vision loss secondary to diabetic macular edema (DME). Methods. A retrospective study was conducted in DME patients treated with ranibizumab. Patients were monitored every 4 weeks for visual acuity (VA) an...

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Bibliographic Details
Published in:Journal of ophthalmology 2018-01, Vol.2018 (2018), p.1-7
Main Authors: Giocanti-Auregan, Audrey, Delahaye-Mazza, Corinne, Quentel, Gabriel, Grenet, Typhaine, Nghiem-Buffet, Sylvia, Fajnkuchen, Franck, Best, Anne-Laurence, Cohen, Salomon Yves
Format: Article
Language:English
Subjects:
Blood pressure
Care and treatment
Diabetes
Diabetic retinopathy
Dropsy
Edema
Immunotherapy
Ischemia
Lasers
Macular degeneration
Medical research
Medicine, Experimental
Monoclonal antibodies
Patient compliance
Patients
Pharmaceutical industry
Sleep apnea
Statistical analysis
Type 2 diabetes
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Summary:Purpose. To assess real-life efficacy of ranibizumab and treatment compliance of patients with vision loss secondary to diabetic macular edema (DME). Methods. A retrospective study was conducted in DME patients treated with ranibizumab. Patients were monitored every 4 weeks for visual acuity (VA) and central retinal thickness (CRT) by SD-OCT. All patients received a loading dose of 3 monthly injections followed by retreatments on an as-needed basis. The primary endpoint was the change in VA at M12. Patient compliance to the follow-up and the correlation between the injection number and VA were also investigated. Compliance was compared to that of neovascular age-related macular degeneration (nAMD) patients. Results. Seventy-two eyes of 55 consecutive DME patients were included. At baseline, the mean VA was 56.5 letters and CRT was 470 μm. At M12, the mean VA was 63.4 letters (p 70 letters, the mean VA change was +6.9 letters, and the mean CRT was 361.9 μm (p=0.0001) after a mean number of 5.33 intravitreal injections. In patients who received ≥7 injections, the VA gain and final VA were significantly higher than in patients who received
ISSN:2090-004X
2090-0058
DOI:10.1155/2018/4610129