Excision of a gastrointestinal stromal tumour in a dog using short‐wave infrared fluorescence imaging and indocyanine green

• Published in: Veterinary medicine and science 2024-07, Vol.10 (4), p.e1506-n/a
• Main Authors: Choi, Jinyoung, Lee, Sungin
• Format: Article
• Language: English
• Subjects: Abdomen; Adjuvants; Animals; Anorexia; Case Report; Chemotherapy; Computed tomography; dog; Dog Diseases - diagnostic imaging; Dog Diseases - surgery; DOGS; Gastrointestinal Stromal Tumors - diagnosis; Gastrointestinal Stromal Tumors - diagnostic imaging; Gastrointestinal Stromal Tumors - surgery; Gastrointestinal Stromal Tumors - veterinary; gastrointestinal stromal tumour; Histopathology; image‐guided surgery; Indocyanine Green; Johnston, S; Male; Mesentery; Metastasis; Optical Imaging - methods; Optical Imaging - veterinary; Surgery; surgical margin; Surgical outcomes; Tomography; Tumors; Ultrasonic imaging
• ISSN: 2053-1095; 2053-1095
• DOI: 10.1002/vms3.1506

A 7‐year‐old castrated male Golden Retriever weighing 36.8 kg presented to the Veterinary Teaching Hospital with vomiting, anorexia and depression. After blood tests, radiographic, ultrasound and computed tomography examinations, a 7.85 × 5.90 × 8.75 cm mass was identified in the caecum. To visualise the tumour margin and improve the accuracy of tumour resection, intraoperative short‐wave infrared imaging using indocyanine green was performed during surgery. An indocyanine green solution was injected intravenously as a bolus of 5 mg/kg 24 h before surgery. Tumour resection was performed with a 0.5 cm margin from the fluorescent‐marked tissues. Histopathological examination revealed a diagnosis of a gastrointestinal stromal tumour (GIST) and the absence of neoplastic cells in the surgical margin, indicating a successful surgery. To our knowledge, this is the first case of a GIST resection in a dog using intraoperative short‐wave infrared imaging. The manuscript describes a clinical case of surgical resection of gastrointestinal stromal tumour using short‐wave infrared (SWIR) fluorescence imaging with indocyanine green in a dog. Using the method, the tumour location was identified and the resection margin was defined before proceeding with the surgery and histopathological examination confirmed complete excision of tumour. As in human medicine, the use of the SWIR method in gastrointestinal surgery for tumour resection was confirmed to be useful in veterinary medicine as well through this clinical case.