Lactobacillus gasseri LG-G12 Restores Gut Microbiota and Intestinal Health in Obesity Mice on Ceftriaxone Therapy

Gut microbiota imbalance is associated with the occurrence of metabolic diseases such as obesity. Thus, its modulation is a promising strategy to restore gut microbiota and improve intestinal health in the obese. This paper examines the role of probiotics, antimicrobials, and diet in modulating gut...

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Published in:Foods 2023-03, Vol.12 (5), p.1092
Main Authors: de Moura E Dias, Mariana, da Silva Duarte, Vinícius, Mota, Lúcio Flávio Macedo, de Cássia Ávila Alpino, Gabriela, Dos Reis Louzano, Sandra Aparecida, da Conceição, Lisiane Lopes, Mantovanie, Hilário Cuquetto, Pereira, Solange Silveira, Oliveira, Leandro Licursi, de Oliveira Mendes, Tiago Antônio, Porcellato, Davide, do Carmo Gouveia Peluzio, Maria
Format: Article
Language:English
Subjects:
Animals
Antigens
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
Ceftriaxone
Chromatography
Diet
Digestive system
Experiments
Fatty acids
Food science
Gastrointestinal tract
Genes
gut microbiota
High fat diet
intestinal health
Intestinal microflora
Intestine
Lactobacillus gasseri
Lactobacillus gasseri LG-G12
Metabolic disorders
Metabolism
Metabolites
Microbiota
Obesity
Permeability
Phylogenetics
Probiotics
Weight control
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Summary:Gut microbiota imbalance is associated with the occurrence of metabolic diseases such as obesity. Thus, its modulation is a promising strategy to restore gut microbiota and improve intestinal health in the obese. This paper examines the role of probiotics, antimicrobials, and diet in modulating gut microbiota and improving intestinal health. Accordingly, obesity was induced in C57BL/6J mice, after which they were redistributed and fed with an obesogenic diet (intervention A) or standard AIN-93 diet (intervention B). Concomitantly, all the groups underwent a treatment phase with LG-G12, ceftriaxone, or ceftriaxone followed by LG-G12. At the end of the experimental period, the following analysis was conducted: metataxonomic analysis, functional profiling of gut microbiota, intestinal permeability, and caecal concentration of short-chain fatty acids. High-fat diet impaired bacterial diversity/richness, which was counteracted in association with LG-G12 and the AIN-93 diet. Additionally, SCFA-producing bacteria were negatively correlated with high intestinal permeability parameters, which was further confirmed via functional profile prediction of the gut microbiota. A novel perspective on anti-obesity probiotics is presented by these findings based on the improvement of intestinal health irrespective of undergoing antimicrobial therapy or not.
ISSN:2304-8158
2304-8158
DOI:10.3390/foods12051092