Real-World Experience with Intracapsular Administration of Dexamethasone Intraocular Suspension 9% for Control of Postoperative Inflammation

Corticosteroids and non-steroidal anti-inflammatory drugs are commonly used prophylactically to control inflammation after ocular surgery. When prescribed as eye drops, as has been longstanding tradition, anti-inflammatory success is out of surgeons' hands, dependent on patient compliance and p...

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Bibliographic Details
Published in:Clinical ophthalmology (Auckland, N.Z.) N.Z.), 2022-06, Vol.16, p.1985-1992
Main Authors: McCabe, Cathleen, Desai, Priya, Nijm, Lisa, Osher, Robert, Weinstock, Robert
Format: Article
Language:English
Subjects:
Bromfenac
Cataract
Cataracts
Central nervous system depressants
Clinical trials
Cornea
corticosteroids
Dexamethasone
Drug approval
Drug delivery systems
Drug dosages
Edema
Endothelium
Eye surgery
Eyewear industry
Inflammation
Patient compliance
Patients
Review
Steroids
Surgeons
Surgery
technique
Work experience
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Summary:Corticosteroids and non-steroidal anti-inflammatory drugs are commonly used prophylactically to control inflammation after ocular surgery. When prescribed as eye drops, as has been longstanding tradition, anti-inflammatory success is out of surgeons' hands, dependent on patient compliance and proper instillation technique. Sustained-release, intraoperatively administered antiinflammatory drugs are emerging as another option. DEXYCU (dexamethasone intraocular suspension) 9% is the first and only intraocular corticosteroid FDA-approved for postoperative inflammation, whose sustained-release formulation provides a high initial release of drug, followed by a gradual tapering. Administration of the drug directly into the capsular bag following cataract surgery enables reliable placement proximal to target tissues, ensuring surgeon control and visibility of delivery, safety, and efficiency. This technique also minimizes contact with metabolically active tissues such as the corneal endothelium, iris, and ciliary body. In this paper, we review the available literature on dexamethasone intraocular suspension and summarize surgeons' consensus on best practices for intracapsular administration. Keywords: cataract, corticosteroids, inflammation, technique
ISSN:1177-5483
1177-5467
1177-5483
DOI:10.2147/OPTH.S361146