Prediction of nonsentinel lymph node metastasis in breast cancer patients with one or two positive sentinel lymph nodes

Objective The aim of the present study was to investigate the association between non sentinel lymph node metastasis (NSLNM) and clinicopathological factors, particularly in the case of sentinel lymph node (SLN) metastasis in one or two, in clinically node negative patients with breast cancer. Metho...

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Bibliographic Details
Published in:Asian journal of surgery 2018-01, Vol.41 (1), p.12-19
Main Authors: Öz, Bahadır, Akcan, Alper, Doğan, Serap, Abdulrezzak, Ümmühan, Aslan, Dicle, Sözüer, Erdoğan, Emek, Ertan, Akyüz, Muhammet, Elmalı, Ferhan, Ok, Engin
Format: Article
Language:English
Subjects:
breast cancer
clinically node negative
extracapsuler invasion
Her-2 status
Ki-67
non sentinel lymph node
Surgery
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Summary:Objective The aim of the present study was to investigate the association between non sentinel lymph node metastasis (NSLNM) and clinicopathological factors, particularly in the case of sentinel lymph node (SLN) metastasis in one or two, in clinically node negative patients with breast cancer. Methods Between 10/2010 and 10/2014, 350 sentinel lymph node biopsy (SLNB) were performed in patients with histologically proven primary breast cancer in our clinic. The data collection includes the following characteristics: age, pathological tumor size, histological type, histological grade, lymphovascular invasion (LVI), number of positive SLN, size of the SLN metastasis (macrometastasis, micrometastasis, isolated tumor cells), multifocality (MF), extracapsuler invasion (ECI) of the SLN, the estrogen receptor (ER) status, the progesterone receptor (PR) status and the Her 2 receptor status, Ki 67 reseptor status. Data were collected retrospectively and then analyzed. Results A successful SLN biopsy were performed in 345 (98.5%) cases. SLN metastases were detected in 110 (31.8%) cases. These patients then underwent axillary dissection; among these patients, 101 (91.8%) had only one to two positive SLNs. Of the 101 patients with positive SLN biopsies, 32 (31.6%) had metastases in the NSLNs. Univariate and multivariate analysis showed that lymphovascular invasion, extracapsular invasion (ECI), Her-2 receptor positive, and Ki-67 > 14% were related to NSLNM (p
ISSN:1015-9584
DOI:10.1016/j.asjsur.2016.06.001