Antiviral activities of Radix isatidis polysaccharide against pseudorabies virus in swine testicle cells

Radix isatidis has been used in China and other Asian countries for its antiviral and anti-inflammatory effects for thousands of years. However, the antiviral effect of Radix isatidis polysaccharide against pseudorabies virus (PRV) is still unknown. The polysaccharide were isolated from extract of t...

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Published in:BMC complementary and alternative medicine 2020-02, Vol.20 (1), p.48-48, Article 48
Main Authors: Tong, Chao, Chen, Zewen, Liu, Fang, Qiao, Yanyan, Chen, Tong, Wang, Xuebing
Format: Article
Language:English
Subjects:
Acids
Antimicrobial agents
Antiviral agents
Antiviral drugs
Aujeszky's disease
Cell culture
Cytotoxicity
Experiments
Health aspects
Herbal medicine
Hogs
Infection
Infections
Inflammation
Influenza
Laboratories
Livestock
Medical research
Medicine
Nervous system
Polysaccharide
Polysaccharides
Pseudorabies
Pseudorabies virus
Radix isatidis
Saccharides
Statistical analysis
Swine
Swine testicle cells
Viruses
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Summary:Radix isatidis has been used in China and other Asian countries for its antiviral and anti-inflammatory effects for thousands of years. However, the antiviral effect of Radix isatidis polysaccharide against pseudorabies virus (PRV) is still unknown. The polysaccharide were isolated from extract of the roots of Radix isatidis. MTT assays were used to determine the preventive effect, inhibitory effect and antiviral effect of Radix isatidis polysaccharide on PRV in vitro. This study found that different concentrations of polysaccharides from this plant can inhibit PRV replication by 14.674-30.840%, prevent infection at rates of 6.668-14.923%, and kill this virus at rates of 32.214-67.422%. These results broaden the understanding of this traditional Chinese herb and provide a theoretical basis for further research. Moreover, Radix isatidis polysaccharide could be used for antiviral therapy.
ISSN:2662-7671
2662-7671
1472-6882
DOI:10.1186/s12906-020-2838-4