Hypertension and cardiac damage in pheochromocytoma and paraganglioma patients: a large-scale single-center cohort study

• Published in: BMC cardiovascular disorders 2024-06, Vol.24 (1), p.325-6, Article 325
• Main Authors: Yu, Yang, Chen, Chuyun, Meng, Lei, Han, Wencong, Zhang, Yan, Zhang, Zheng, Yang, Ying
• Format: Article
• Language: English
• Subjects: Abdomen; Adrenal Gland Neoplasms - complications; Adrenal Gland Neoplasms - diagnostic imaging; Adrenal Gland Neoplasms - epidemiology; Adrenal Gland Neoplasms - surgery; Adult; Aged; Asymptomatic; Back pain; Blood Pressure; Body mass index; Catecholamines; Cohort analysis; Creatinine; Demographics; Development and progression; Diabetes; Diabetes mellitus; Echocardiography; Female; Headaches; Heart; Hospitalization; Humans; Hypertension; Hypertension - epidemiology; Hypertrophy; Left ventricular hypertrophy; Left ventricular mass index; Male; Middle Aged; Neuroendocrine tumors; Paraganglioma; Paraganglioma - complications; Paraganglioma - diagnostic imaging; Paraganglioma - epidemiology; Paragangliomas; Patients; Pheochromocytoma; Pheochromocytoma - complications; Pheochromocytoma - diagnostic imaging; Pheochromocytoma - epidemiology; Pheochromocytoma - surgery; Prevalence; Retrospective Studies; Risk Assessment; Risk Factors; Statistical analysis; Structure-function relationships; Surgery; Tumors; Values; Ventricle; Ventricular Function, Left; Ventricular Remodeling
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-024-03936-6

Hypertension (HT) is one of the most common manifestations in patients with catecholamine-secreting neuroendocrine tumors. Although the cardiovascular manifestations of these tumors have been described, there have been no large-scale investigations of the profile of HT and changes in cardiac structure and function that occur in patients with pheochromocytomas and paragangliomas (PPGL). In this study, we investigated the prevalence of HT and left ventricular remodeling (LVR) in a cohort of 598 patients who underwent surgery for PPGL at our center between January 2001 and April 2022. Information on demographics, reason for hospitalization, medical history, biochemical parameters, findings on echocardiography, and tumor characteristics were recorded. The LVR index was compared according to whether or not there was a history of HT. The average age was 47.07 ± 15.07 years, and 277 (46.32%) of the patients were male. A history of HT was found in 423 (70.74%) of the 598 patients. Paraganglioma was significantly more common in the group with HT (26.00% vs. 17.71%, P = 0.030) and significantly less likely to be found incidentally during a health check-up in this group (22.93% vs. 59.43%, P