Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma

Epithelial-mesenchymal transition (EMT) is a critical process that occurs during the embryonic development, wound healing, organ fibrosis and the onset of malignancy. Emerging evidence suggests that the EMT is involved in the invasion and metastasis of cancers. The inflammatory reaction antecedent t...

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Bibliographic Details
Published in:The Japanese dental science review 2020-11, Vol.56 (1), p.97-108
Main Authors: Shetty, Smitha Sammith, Sharma, Mohit, Fonseca, Felipe Paiva, Jayaram, Pradyumna, Tanwar, Ankit Singh, Kabekkodu, Shama Prasada, Satyamoorthy, Kapaettu, Radhakrishnan, Raghu
Format: Article
Language:English
Subjects:
Epithelial-mesenchymal transition (EMT)
Functional enrichment
Oral squamous cell carcinoma (OSCC)
Oral submucous fibrosis (OSF)
Signaling pathways in EMT
Transcription factors in EMT
Type II EMT
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Summary:Epithelial-mesenchymal transition (EMT) is a critical process that occurs during the embryonic development, wound healing, organ fibrosis and the onset of malignancy. Emerging evidence suggests that the EMT is involved in the invasion and metastasis of cancers. The inflammatory reaction antecedent to fibrosis in the onset of oral submucous fibrosis (OSF) and the role of EMT in its malignant transformation indicates a hitherto unexplored involvement of EMT. This review focuses on the role of EMT markers which are regulators of the EMT mediated complex network of molecular mechanisms involved in the pathogenesis of OSF and OSCC. Further the gene enrichment analysis and pathway analysis supports the association of the upregulated and downregulated genes in various EMT regulating pathways.
ISSN:1882-7616
2213-6851
DOI:10.1016/j.jdsr.2020.07.002