Biologically Aggressive Phenotype and Anti-cancer Immunity Counterbalance in Breast Cancer with High Mutation Rate

While cancer cells gain aggressiveness by mutations, abundant mutations release neoantigens, attracting anti-cancer immune cells. We hypothesized that in breast cancer (BC), where mutation is less common, tumors with high mutation rates demonstrate aggressive phenotypes and attract immune cells simu...

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Bibliographic Details
Published in:Scientific reports 2020-02, Vol.10 (1), p.1852-1852, Article 1852
Main Authors: Takahashi, Hideo, Asaoka, Mariko, Yan, Li, Rashid, Omar M., Oshi, Masanori, Ishikawa, Takashi, Nagahashi, Masayuki, Takabe, Kazuaki
Format: Article
Language:English
Subjects:
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Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - immunology
Cell proliferation
Cell Proliferation - genetics
Cytidine Deaminase - genetics
Cytidine Deaminase - immunology
Cytolytic activity
Female
Gene expression
Gene Expression Regulation, Neoplastic - genetics
Gene Expression Regulation, Neoplastic - immunology
Homologous recombination
Humanities and Social Sciences
Humans
Immunity
Immunity - genetics
Immunity - immunology
Immunogenicity
Lymphocytes
Lymphocytes - immunology
Lymphocytes T
Macrophages
Macrophages - immunology
Metastases
Middle Aged
multidisciplinary
Mutation
Mutation - genetics
Mutation - immunology
Mutation Rate
Mutation rates
Neoantigens
Phenotype
Phenotypes
Receptors, Antigen, T-Cell - immunology
RNA, Messenger - genetics
RNA, Messenger - immunology
Science
Science (multidisciplinary)
Survival
Survival Rate
T cell receptors
Tumors
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Summary:While cancer cells gain aggressiveness by mutations, abundant mutations release neoantigens, attracting anti-cancer immune cells. We hypothesized that in breast cancer (BC), where mutation is less common, tumors with high mutation rates demonstrate aggressive phenotypes and attract immune cells simultaneously. High mutation rates were defined as the top 10% of the mutation rate, utilizing TCGA and METABRIC transcriptomic data. Mutation rate did not impact survival although high mutation BCs were associated with aggressive clinical features, such as more frequent in ER-negative tumors (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-58995-4