Liver Transplantation in a Patient with Acquired Dysfibrinogenemia Who Presented with Subdural Hematoma: A Case Report

Fibrinogen is one of the most abundant proteins in the blood; normal levels range from 200 to 400 mg/dL. Fibrinogen is synthesized in the liver and is essential for the clotting of blood. It also binds to platelets, supports aggregation, and plays an important role in wound healing. Fibrinogen defic...

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Bibliographic Details
Published in:Turkish journal of haematology 2017-12, Vol.34 (4), p.356-381
Main Authors: Acar, Şencan, Güngör, Gökhan, Dayangaç, Murat, Diz-Küçükkaya, Reyhan, Tokat, Yaman, Akyıldız, Murat
Format: Article
Language:English
Subjects:
Anticoagulants
Consciousness
dysfibrinogenemia
Hemorrhage
Laboratories
Letter to the Editor
Liver cirrhosis
Liver diseases
liver transplantation
Medical imaging
Patients
subdural hematoma
Tıp
Transplants & implants
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Summary:Fibrinogen is one of the most abundant proteins in the blood; normal levels range from 200 to 400 mg/dL. Fibrinogen is synthesized in the liver and is essential for the clotting of blood. It also binds to platelets, supports aggregation, and plays an important role in wound healing. Fibrinogen deficiencies can be caused by decreased levels (hypo- or afibrinogenemia) or defective function (dysfibrinogenemia). Dysfibrinogenemia may either be autosomal dominantly inherited or acquired and it can manifest as bleeding or thrombotic events, or in some cases both simultaneously. Situations causing acquired dysfibrinogenemia include chronic liver disease, malignancies, and autoimmune diseases. Herein, we report a liver transplant recipient with dysfibrinogenemia who presented with subdural hematoma due to liver cirrhosis.
ISSN:1300-7777
1308-5263
DOI:10.4274/tjh.2017.0045