Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson’s patients

Pathologically increased beta power has been described as a biomarker for Parkinson’s disease (PD) and related to prolonged bursts of subthalamic beta synchronization. Here, we investigate the association between subthalamic beta dynamics and motor impairment in a cohort of 106 Parkinson’s patients...

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Bibliographic Details
Published in:NPJ Parkinson's Disease 2023-01, Vol.9 (1), p.2-2, Article 2
Main Authors: Lofredi, Roxanne, Okudzhava, Liana, Irmen, Friederike, Brücke, Christof, Huebl, Julius, Krauss, Joachim K., Schneider, Gerd-Helge, Faust, Katharina, Neumann, Wolf-Julian, Kühn, Andrea A.
Format: Article
Language:English
Subjects:
631/378/2632/1323
692/53/2423
692/617/375/1718
Biomarkers
Biomedical and Life Sciences
Biomedicine
Control algorithms
Deep brain stimulation
Dopamine
Neurology
Neurosciences
Neurosurgery
Parkinson's disease
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Summary:Pathologically increased beta power has been described as a biomarker for Parkinson’s disease (PD) and related to prolonged bursts of subthalamic beta synchronization. Here, we investigate the association between subthalamic beta dynamics and motor impairment in a cohort of 106 Parkinson’s patients in the ON- and OFF-medication state, using two different methods of beta burst determination. We report a frequency-specific correlation of low beta power and burst duration with motor impairment OFF dopaminergic medication. Furthermore, reduction of power and burst duration correlated significantly with symptom alleviation through dopaminergic medication. Importantly, qualitatively similar results were yielded with two different methods of beta burst definition. Our findings validate the robustness of previous results on pathological changes in subcortical oscillations both in the frequency- as well as in the time-domain in the largest cohort of PD patients to date with important implications for next-generation adaptive deep brain stimulation control algorithms.
ISSN:2373-8057
2373-8057
DOI:10.1038/s41531-022-00443-3