Confirmed value of shear wave elastography for ultrasound characterization of breast masses using a conservative approach in Chinese women: a large-size prospective multicenter trial

This study aimed to investigate the value of shear wave elastography (SWE) for characterization of breast masses in a Chinese population. Two thousand two hundred seventy-three women consented to be prospectively enrolled for the characterization of breast masses with ultrasound and SWE. Breast mass...

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Bibliographic Details
Published in:Cancer management and research 2018-01, Vol.10, p.4447-4458
Main Authors: Lin, Xi, Chang, Cai, Wu, Changjun, Chen, Qin, Peng, Yulan, Luo, Baoming, Tang, Lina, Li, Jing, Zheng, Jihui, Zhou, Ruhai, Cui, Guanghe, Li, Ao, Wang, Xuemei, Qian, Linxue, Zhang, Jianxing, Wen, Chaoyang, Gay, Joel, Zhang, Huili, Li, Anhua, Chen, Yaling
Format: Article
Language:English
Subjects:
Biopsy
Breast cancer
Breast tumors
Care and treatment
Diagnosis
Diagnostic imaging
Ethics
Histochemistry
Mammography
Medical screening
multicenter
Original Research
Population growth
ShearWave Elastography
Studies
Ultrasonic imaging
ultrasound
Ultrasound imaging
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Summary:This study aimed to investigate the value of shear wave elastography (SWE) for characterization of breast masses in a Chinese population. Two thousand two hundred seventy-three women consented to be prospectively enrolled for the characterization of breast masses with ultrasound and SWE. Breast masses were known from symptoms, palpability, and/or previous imaging screening with mammography and/or ultrasound. Correlation of SWE qualitative and quantitative features with malignancy risk and impact on diagnostic performance of combining SWE features were assessed, and the Breast Imaging Reporting and Data System (BI-RADS) scoring was calculated using histopathology as reference. Data of 2,262 masses (median size: 13 mm; range: 1.3-50) from 2,262 patients (median age: 43 years; range: 18-91) were investigated, of which 752 (33.3%) were malignant. Sensitivity and specificity of BI-RADS diagnosis were 97.5% (733/752) and 54.8% (827/1,510), respectively. By logistic regression, the combination of maximum elasticity ( ) measurements with BI-RADS assessments increased the area under the receiver operating characteristic curve from 0.908 (95% CI: 0.896-0.920) to 0.954 (95% CI: 0.944-0.962). Using of 30 kPa or lower to selectively downgrade BI-RADS 4a masses to follow-up, and of 160 kPa or higher to selectively upgrade BI-RADS 3 lesions to biopsy, specificity significantly increased from 54.8% (827/1,510) to 66.1% (998/1,510) (
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S174690