Metabolic dysfunction-related liver disease as a risk factor for cancer

The aim of this study was to investigate the association between obesity, diabetes and metabolic related liver dysfunction and the incidence of cancer. This study was conducted with health record data available from the National Health Service in Tayside and Fife. Genetics of Diabetes Audit and Rese...

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Bibliographic Details
Published in:BMJ open gastroenterology 2022-03, Vol.9 (1), p.e000817
Main Authors: Taylor, Alasdair, Siddiqui, Moneeza K, Ambery, Philip, Armisen, Javier, Challis, Benjamin G, Haefliger, Carolina, Pearson, Ewan R, Doney, Alex S F, Dillon, John F, Palmer, Colin N A
Format: Article
Language:English
Subjects:
Age
Body mass index
Cancer
Cell cycle
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - epidemiology
Electronic health records
Females
Humans
Liver cancer
Liver diseases
Medical records
Medical research
Metabolic Diseases - complications
Metabolism
Neoplasms - complications
Neoplasms - etiology
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - epidemiology
Obesity
Obesity - complications
Obesity - epidemiology
Risk Factors
State Medicine
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Summary:The aim of this study was to investigate the association between obesity, diabetes and metabolic related liver dysfunction and the incidence of cancer. This study was conducted with health record data available from the National Health Service in Tayside and Fife. Genetics of Diabetes Audit and Research Tayside, Scotland (GoDARTS), Scottish Health Research Register (SHARE) and Tayside and Fife diabetics, three Scottish cohorts of 13 695, 62 438 and 16 312 patients, respectively, were analysed in this study. Participants in GoDARTS were a volunteer sample, with half having type 2 diabetes mellitus(T2DM). SHARE was a volunteer sample. Tayside and Fife diabetics was a population-level cohort. Metabolic dysfunction-related liver disease (MDLD) was defined using alanine transaminase measurements, and individuals with alternative causes of liver disease (alcohol abuse, viruses, etc) were excluded from the analysis. MDLD associated with increased cancer incidence with a HR of 1.31 in a Cox proportional hazards model adjusted for sex, type 2 diabetes, body mass index(BMI), and smoking status (95% CI 1.27 to 1.35, p
ISSN:2054-4774
2054-4774
DOI:10.1136/bmjgast-2021-000817