Natural Products from Singapore Soil-Derived Streptomycetaceae Family and Evaluation of Their Biological Activities

Natural products have long been used as a source of antimicrobial agents against various microorganisms. Actinobacteria are a group of bacteria best known to produce a wide variety of bioactive secondary metabolites, including many antimicrobial agents. In this study, four actinobacterial strains fo...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2023-08, Vol.28 (15), p.5832
Main Authors: Chin, Elaine-Jinfeng, Ching, Kuan-Chieh, Tan, Zann Y, Wibowo, Mario, Leong, Chung-Yan, Yang, Lay-Kien, Ng, Veronica W P, Seow, Deborah C S, Kanagasundaram, Yoganathan, Ng, Siew-Bee
Format: Article
Language:English
Subjects:
actinobacteria
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - pharmacology
Antibiotics
antimicrobial
Antimicrobial agents
Bacteria
Bioassays
Biological Products - chemistry
Biological Products - pharmacology
Carbohydrates
Carbon
Cytotoxicity
Drug resistance
Fermentation
Metabolism
Metabolites
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests
Microorganisms
Natural products
Nitrogen
Pancreatic cancer
Pathogens
Phylogenetics
Singapore
Staphylococcus aureus
Staphylococcus infections
Streptomycetaceae
tetronomycin
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Summary:Natural products have long been used as a source of antimicrobial agents against various microorganisms. Actinobacteria are a group of bacteria best known to produce a wide variety of bioactive secondary metabolites, including many antimicrobial agents. In this study, four actinobacterial strains found in Singapore terrestrial soil were investigated as potential sources of new antimicrobial compounds. Large-scale cultivation, chemical, and biological investigation led to the isolation of a previously undescribed tetronomycin A ( ) that demonstrated inhibitory activities against both Gram-positive bacteria (SA) and methicillin-resistant (MRSA) (i.e., MIC of 2-4 μM and MBC of 9-12 μM), and several known antimicrobial compounds, namely nonactin, monactin, dinactin, 4E-deacetylchromomycin A3, chromomycin A2, soyasaponin II, lysolipin I, tetronomycin, and naphthomevalin. Tetronomycin showed a two- to six-fold increase in antibacterial activity (i.e., MIC and MBC of 1-2 μM) as compared to tetronomycin A ( ), indicating the presence of an oxy-methyl group at the C-27 position is important for antibacterial activity.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28155832