Regulation and Directing Stem Cell Fate by Tissue Engineering Functional Microenvironments: Scaffold Physical and Chemical Cues

It is well known that stem cells reside within tissue engineering functional microenvironments that physically localize them and direct their stem cell fate. Recent efforts in the development of more complex and engineered scaffold technologies, together with new understanding of stem cell behavior...

Full description

Saved in:
Bibliographic Details
Published in:Stem cells international 2019, Vol.2019 (2019), p.1-16
Main Authors: Zhang, Xingdong, Xiang, Zhou, Kong, Qingquan, Lei, Haoyuan, Wu, Lina, Long, Cheng, Zhou, Changchun, Li, Lang, Xing, Fei, Fan, Yujiang
Format: Article
Language:English
Subjects:
3-D printers
Biocompatibility
Biomedical materials
Bones
Cell adhesion
Cell fate
Cell growth
Chemical stimuli
Embryos
Gene expression
Growth factors
Kinases
Mechanical properties
Mechanical stimuli
Methods
Microenvironments
Organic chemistry
Physical factors
Porosity
Researchers
Review
Scaffolds
Stem cells
Stiffness
Tissue engineering
Topography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c603t-681037c6aa5076414342b80ebcf74ada92597e8968f954227f19b5ebd0b2fb283
cites cdi_FETCH-LOGICAL-c603t-681037c6aa5076414342b80ebcf74ada92597e8968f954227f19b5ebd0b2fb283
container_end_page 16
container_issue 2019
container_start_page 1
container_title Stem cells international
container_volume 2019
creator Zhang, Xingdong
Xiang, Zhou
Kong, Qingquan
Lei, Haoyuan
Wu, Lina
Long, Cheng
Zhou, Changchun
Li, Lang
Xing, Fei
Fan, Yujiang
description It is well known that stem cells reside within tissue engineering functional microenvironments that physically localize them and direct their stem cell fate. Recent efforts in the development of more complex and engineered scaffold technologies, together with new understanding of stem cell behavior in vitro, have provided a new impetus to study regulation and directing stem cell fate. A variety of tissue engineering technologies have been developed to regulate the fate of stem cells. Traditional methods to change the fate of stem cells are adding growth factors or some signaling pathways. In recent years, many studies have revealed that the geometrical microenvironment played an essential role in regulating the fate of stem cells, and the physical factors of scaffolds including mechanical properties, pore sizes, porosity, surface stiffness, three-dimensional structures, and mechanical stimulation may affect the fate of stem cells. Chemical factors such as cell-adhesive ligands and exogenous growth factors would also regulate the fate of stem cells. Understanding how these physical and chemical cues affect the fate of stem cells is essential for building more complex and controlled scaffolds for directing stem cell fate.
doi_str_mv 10.1155/2019/2180925
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_80abed23368c40a89a8c0fb3dbacdc54</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_80abed23368c40a89a8c0fb3dbacdc54</doaj_id><sourcerecordid>2341617438</sourcerecordid><originalsourceid>FETCH-LOGICAL-c603t-681037c6aa5076414342b80ebcf74ada92597e8968f954227f19b5ebd0b2fb283</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhiMEolXpjTOyxAWJLvVXHJtDJbR0oVIRiBaJm2U7k12vEqfYSas98ddxustCOeGLv555PTN-i-I5wW8IKctTiok6pURiRctHxSERspopUcnH-7X4flAcp7TGeTCFOaZPiwNGFFecicPi51dYjq0ZfB-QCTV67yO4wYcluhqgQ3NoW7QwAyC7Qdc-pRHQeVj6ABAnaDEGN8WaFn3yLvYQbn3sQwdhSG_RlTNN07c1-rLaJO8yND0xX0F3v5mPkJ4VTxrTJjjezUfFt8X59fzj7PLzh4v5u8uZE5gNMyEJZpUTxpS4EpxwxqmVGKxrKm5qk8tXFUglZKNKTmnVEGVLsDW2tLFUsqPiYqtb92atb6LvTNzo3nh9f9DHpTZx8K4FLbGxUFPGhHQcG6mMdLixrLbG1a7kWetsq3Uz2g5ql4uNpn0g-vAm-JVe9rdaKC4ZVVng1U4g9j9yEwbd-eRyq02AfkyaMk4EqTib8n75D7rux5j7PVGMqUpIKjJ1sqXyF6QUodknQ7CejKIno-idUTL-4u8C9vBvW2Tg9RZY-VCbO_-fcpAZaMwfmmLJlGS_AE3c0GI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2333976826</pqid></control><display><type>article</type><title>Regulation and Directing Stem Cell Fate by Tissue Engineering Functional Microenvironments: Scaffold Physical and Chemical Cues</title><source>Open Access: PubMed Central</source><source>Wiley Online Library Open Access</source><source>Publicly Available Content (ProQuest)</source><creator>Zhang, Xingdong ; Xiang, Zhou ; Kong, Qingquan ; Lei, Haoyuan ; Wu, Lina ; Long, Cheng ; Zhou, Changchun ; Li, Lang ; Xing, Fei ; Fan, Yujiang</creator><contributor>Montesi, Monica ; Monica Montesi</contributor><creatorcontrib>Zhang, Xingdong ; Xiang, Zhou ; Kong, Qingquan ; Lei, Haoyuan ; Wu, Lina ; Long, Cheng ; Zhou, Changchun ; Li, Lang ; Xing, Fei ; Fan, Yujiang ; Montesi, Monica ; Monica Montesi</creatorcontrib><description>It is well known that stem cells reside within tissue engineering functional microenvironments that physically localize them and direct their stem cell fate. Recent efforts in the development of more complex and engineered scaffold technologies, together with new understanding of stem cell behavior in vitro, have provided a new impetus to study regulation and directing stem cell fate. A variety of tissue engineering technologies have been developed to regulate the fate of stem cells. Traditional methods to change the fate of stem cells are adding growth factors or some signaling pathways. In recent years, many studies have revealed that the geometrical microenvironment played an essential role in regulating the fate of stem cells, and the physical factors of scaffolds including mechanical properties, pore sizes, porosity, surface stiffness, three-dimensional structures, and mechanical stimulation may affect the fate of stem cells. Chemical factors such as cell-adhesive ligands and exogenous growth factors would also regulate the fate of stem cells. Understanding how these physical and chemical cues affect the fate of stem cells is essential for building more complex and controlled scaffolds for directing stem cell fate.</description><identifier>ISSN: 1687-966X</identifier><identifier>EISSN: 1687-9678</identifier><identifier>DOI: 10.1155/2019/2180925</identifier><identifier>PMID: 31949436</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>3-D printers ; Biocompatibility ; Biomedical materials ; Bones ; Cell adhesion ; Cell fate ; Cell growth ; Chemical stimuli ; Embryos ; Gene expression ; Growth factors ; Kinases ; Mechanical properties ; Mechanical stimuli ; Methods ; Microenvironments ; Organic chemistry ; Physical factors ; Porosity ; Researchers ; Review ; Scaffolds ; Stem cells ; Stiffness ; Tissue engineering ; Topography</subject><ispartof>Stem cells international, 2019, Vol.2019 (2019), p.1-16</ispartof><rights>Copyright © 2019 Fei Xing et al.</rights><rights>Copyright © 2019 Fei Xing et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2019 Fei Xing et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c603t-681037c6aa5076414342b80ebcf74ada92597e8968f954227f19b5ebd0b2fb283</citedby><cites>FETCH-LOGICAL-c603t-681037c6aa5076414342b80ebcf74ada92597e8968f954227f19b5ebd0b2fb283</cites><orcidid>0000-0001-9706-3224 ; 0000-0003-0573-0400 ; 0000-0003-1476-9374</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2333976826/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2333976826?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,25753,27923,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31949436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Montesi, Monica</contributor><contributor>Monica Montesi</contributor><creatorcontrib>Zhang, Xingdong</creatorcontrib><creatorcontrib>Xiang, Zhou</creatorcontrib><creatorcontrib>Kong, Qingquan</creatorcontrib><creatorcontrib>Lei, Haoyuan</creatorcontrib><creatorcontrib>Wu, Lina</creatorcontrib><creatorcontrib>Long, Cheng</creatorcontrib><creatorcontrib>Zhou, Changchun</creatorcontrib><creatorcontrib>Li, Lang</creatorcontrib><creatorcontrib>Xing, Fei</creatorcontrib><creatorcontrib>Fan, Yujiang</creatorcontrib><title>Regulation and Directing Stem Cell Fate by Tissue Engineering Functional Microenvironments: Scaffold Physical and Chemical Cues</title><title>Stem cells international</title><addtitle>Stem Cells Int</addtitle><description>It is well known that stem cells reside within tissue engineering functional microenvironments that physically localize them and direct their stem cell fate. Recent efforts in the development of more complex and engineered scaffold technologies, together with new understanding of stem cell behavior in vitro, have provided a new impetus to study regulation and directing stem cell fate. A variety of tissue engineering technologies have been developed to regulate the fate of stem cells. Traditional methods to change the fate of stem cells are adding growth factors or some signaling pathways. In recent years, many studies have revealed that the geometrical microenvironment played an essential role in regulating the fate of stem cells, and the physical factors of scaffolds including mechanical properties, pore sizes, porosity, surface stiffness, three-dimensional structures, and mechanical stimulation may affect the fate of stem cells. Chemical factors such as cell-adhesive ligands and exogenous growth factors would also regulate the fate of stem cells. Understanding how these physical and chemical cues affect the fate of stem cells is essential for building more complex and controlled scaffolds for directing stem cell fate.</description><subject>3-D printers</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Bones</subject><subject>Cell adhesion</subject><subject>Cell fate</subject><subject>Cell growth</subject><subject>Chemical stimuli</subject><subject>Embryos</subject><subject>Gene expression</subject><subject>Growth factors</subject><subject>Kinases</subject><subject>Mechanical properties</subject><subject>Mechanical stimuli</subject><subject>Methods</subject><subject>Microenvironments</subject><subject>Organic chemistry</subject><subject>Physical factors</subject><subject>Porosity</subject><subject>Researchers</subject><subject>Review</subject><subject>Scaffolds</subject><subject>Stem cells</subject><subject>Stiffness</subject><subject>Tissue engineering</subject><subject>Topography</subject><issn>1687-966X</issn><issn>1687-9678</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNkk1v1DAQhiMEolXpjTOyxAWJLvVXHJtDJbR0oVIRiBaJm2U7k12vEqfYSas98ddxustCOeGLv555PTN-i-I5wW8IKctTiok6pURiRctHxSERspopUcnH-7X4flAcp7TGeTCFOaZPiwNGFFecicPi51dYjq0ZfB-QCTV67yO4wYcluhqgQ3NoW7QwAyC7Qdc-pRHQeVj6ABAnaDEGN8WaFn3yLvYQbn3sQwdhSG_RlTNN07c1-rLaJO8yND0xX0F3v5mPkJ4VTxrTJjjezUfFt8X59fzj7PLzh4v5u8uZE5gNMyEJZpUTxpS4EpxwxqmVGKxrKm5qk8tXFUglZKNKTmnVEGVLsDW2tLFUsqPiYqtb92atb6LvTNzo3nh9f9DHpTZx8K4FLbGxUFPGhHQcG6mMdLixrLbG1a7kWetsq3Uz2g5ql4uNpn0g-vAm-JVe9rdaKC4ZVVng1U4g9j9yEwbd-eRyq02AfkyaMk4EqTib8n75D7rux5j7PVGMqUpIKjJ1sqXyF6QUodknQ7CejKIno-idUTL-4u8C9vBvW2Tg9RZY-VCbO_-fcpAZaMwfmmLJlGS_AE3c0GI</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Zhang, Xingdong</creator><creator>Xiang, Zhou</creator><creator>Kong, Qingquan</creator><creator>Lei, Haoyuan</creator><creator>Wu, Lina</creator><creator>Long, Cheng</creator><creator>Zhou, Changchun</creator><creator>Li, Lang</creator><creator>Xing, Fei</creator><creator>Fan, Yujiang</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-9706-3224</orcidid><orcidid>https://orcid.org/0000-0003-0573-0400</orcidid><orcidid>https://orcid.org/0000-0003-1476-9374</orcidid></search><sort><creationdate>2019</creationdate><title>Regulation and Directing Stem Cell Fate by Tissue Engineering Functional Microenvironments: Scaffold Physical and Chemical Cues</title><author>Zhang, Xingdong ; Xiang, Zhou ; Kong, Qingquan ; Lei, Haoyuan ; Wu, Lina ; Long, Cheng ; Zhou, Changchun ; Li, Lang ; Xing, Fei ; Fan, Yujiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c603t-681037c6aa5076414342b80ebcf74ada92597e8968f954227f19b5ebd0b2fb283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>3-D printers</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Bones</topic><topic>Cell adhesion</topic><topic>Cell fate</topic><topic>Cell growth</topic><topic>Chemical stimuli</topic><topic>Embryos</topic><topic>Gene expression</topic><topic>Growth factors</topic><topic>Kinases</topic><topic>Mechanical properties</topic><topic>Mechanical stimuli</topic><topic>Methods</topic><topic>Microenvironments</topic><topic>Organic chemistry</topic><topic>Physical factors</topic><topic>Porosity</topic><topic>Researchers</topic><topic>Review</topic><topic>Scaffolds</topic><topic>Stem cells</topic><topic>Stiffness</topic><topic>Tissue engineering</topic><topic>Topography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xingdong</creatorcontrib><creatorcontrib>Xiang, Zhou</creatorcontrib><creatorcontrib>Kong, Qingquan</creatorcontrib><creatorcontrib>Lei, Haoyuan</creatorcontrib><creatorcontrib>Wu, Lina</creatorcontrib><creatorcontrib>Long, Cheng</creatorcontrib><creatorcontrib>Zhou, Changchun</creatorcontrib><creatorcontrib>Li, Lang</creatorcontrib><creatorcontrib>Xing, Fei</creatorcontrib><creatorcontrib>Fan, Yujiang</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Stem cells international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xingdong</au><au>Xiang, Zhou</au><au>Kong, Qingquan</au><au>Lei, Haoyuan</au><au>Wu, Lina</au><au>Long, Cheng</au><au>Zhou, Changchun</au><au>Li, Lang</au><au>Xing, Fei</au><au>Fan, Yujiang</au><au>Montesi, Monica</au><au>Monica Montesi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation and Directing Stem Cell Fate by Tissue Engineering Functional Microenvironments: Scaffold Physical and Chemical Cues</atitle><jtitle>Stem cells international</jtitle><addtitle>Stem Cells Int</addtitle><date>2019</date><risdate>2019</risdate><volume>2019</volume><issue>2019</issue><spage>1</spage><epage>16</epage><pages>1-16</pages><issn>1687-966X</issn><eissn>1687-9678</eissn><abstract>It is well known that stem cells reside within tissue engineering functional microenvironments that physically localize them and direct their stem cell fate. Recent efforts in the development of more complex and engineered scaffold technologies, together with new understanding of stem cell behavior in vitro, have provided a new impetus to study regulation and directing stem cell fate. A variety of tissue engineering technologies have been developed to regulate the fate of stem cells. Traditional methods to change the fate of stem cells are adding growth factors or some signaling pathways. In recent years, many studies have revealed that the geometrical microenvironment played an essential role in regulating the fate of stem cells, and the physical factors of scaffolds including mechanical properties, pore sizes, porosity, surface stiffness, three-dimensional structures, and mechanical stimulation may affect the fate of stem cells. Chemical factors such as cell-adhesive ligands and exogenous growth factors would also regulate the fate of stem cells. Understanding how these physical and chemical cues affect the fate of stem cells is essential for building more complex and controlled scaffolds for directing stem cell fate.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>31949436</pmid><doi>10.1155/2019/2180925</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0001-9706-3224</orcidid><orcidid>https://orcid.org/0000-0003-0573-0400</orcidid><orcidid>https://orcid.org/0000-0003-1476-9374</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1687-966X
ispartof Stem cells international, 2019, Vol.2019 (2019), p.1-16
issn 1687-966X
1687-9678
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_80abed23368c40a89a8c0fb3dbacdc54
source Open Access: PubMed Central; Wiley Online Library Open Access; Publicly Available Content (ProQuest)
subjects 3-D printers
Biocompatibility
Biomedical materials
Bones
Cell adhesion
Cell fate
Cell growth
Chemical stimuli
Embryos
Gene expression
Growth factors
Kinases
Mechanical properties
Mechanical stimuli
Methods
Microenvironments
Organic chemistry
Physical factors
Porosity
Researchers
Review
Scaffolds
Stem cells
Stiffness
Tissue engineering
Topography
title Regulation and Directing Stem Cell Fate by Tissue Engineering Functional Microenvironments: Scaffold Physical and Chemical Cues
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T20%3A15%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Regulation%20and%20Directing%20Stem%20Cell%20Fate%20by%20Tissue%20Engineering%20Functional%20Microenvironments:%20Scaffold%20Physical%20and%20Chemical%20Cues&rft.jtitle=Stem%20cells%20international&rft.au=Zhang,%20Xingdong&rft.date=2019&rft.volume=2019&rft.issue=2019&rft.spage=1&rft.epage=16&rft.pages=1-16&rft.issn=1687-966X&rft.eissn=1687-9678&rft_id=info:doi/10.1155/2019/2180925&rft_dat=%3Cproquest_doaj_%3E2341617438%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c603t-681037c6aa5076414342b80ebcf74ada92597e8968f954227f19b5ebd0b2fb283%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2333976826&rft_id=info:pmid/31949436&rfr_iscdi=true