Effect of transmission intensity on hotspots and micro-epidemiology of malaria in sub-Saharan Africa

Malaria transmission intensity is heterogeneous, complicating the implementation of malaria control interventions. We provide a description of the spatial micro-epidemiology of symptomatic malaria and asymptomatic parasitaemia in multiple sites. We assembled data from 19 studies conducted between 19...

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Bibliographic Details
Published in:BMC medicine 2017-06, Vol.15 (1), p.121-121, Article 121
Main Authors: Mogeni, Polycarp, Omedo, Irene, Nyundo, Christopher, Kamau, Alice, Noor, Abdisalan, Bejon, Philip
Format: Article
Language:English
Subjects:
Africa South of the Sahara
Analysis
Clinics
Cluster Analysis
Clustering
D function
Data processing
Disease hot spots
Disease transmission
Epidemiology
Extreme values
Health surveillance
Hotspots
Humans
Infections
Intervention
Malaria
Malaria - epidemiology
Malaria - prevention & control
Malaria - transmission
Meta-analysis
Micro-epidemiology
Mosquitoes
Odds Ratio
Parameter identification
Parasites
Spatial data
Spatial distribution
Stability analysis
Stability of hotspots
Statistical significance
Statistics
Sub-Saharan Africa
Trends
Vector-borne diseases
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Summary:Malaria transmission intensity is heterogeneous, complicating the implementation of malaria control interventions. We provide a description of the spatial micro-epidemiology of symptomatic malaria and asymptomatic parasitaemia in multiple sites. We assembled data from 19 studies conducted between 1996 and 2015 in seven countries of sub-Saharan Africa with homestead-level geospatial data. Data from each site were used to quantify spatial autocorrelation and examine the temporal stability of hotspots. Parameters from these analyses were examined to identify trends over varying transmission intensity. Significant hotspots of malaria transmission were observed in most years and sites. The risk ratios of malaria within hotspots were highest at low malaria positive fractions (MPFs) and decreased with increasing MPF (p 
ISSN:1741-7015
1741-7015
DOI:10.1186/s12916-017-0887-4