Deciphering the assembly process of PQQ dependent methanol dehydrogenase

Pyrroloquinoline quinone (PQQ)-dependent methanol dehydrogenases (MDHs), the periplasmic metalloenzymes in Gram-negative methylotrophic bacteria, play a pivotal role in methane and methanol bio-utilization. Although the structures of many PQQ-dependent MDHs have been resolved, including the canonica...

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Bibliographic Details
Published in:	Nature communications 2025-07, Vol.16 (1), p.6672-11, Article 6672
Main Authors:	Zhou, Haichuan, Sun, Junqing, Cheng, Jian, Wu, Min, Bai, Jie, Li, Qian, Shen, Jie, Han, Manman, Yang, Chen, Li, Liangpo, Liu, Yuwan, Cao, Qichen, Liu, Weidong, Xiao, Haixia, Dong, Hongjun, Gao, Feng, Jiang, Huifeng
Format:	Article
Language:	English
Subjects:	101/28 631/326/47/4113 631/45/607/1163 631/535/1258/1259 631/553/552 631/57/2271 82/58 82/83 Alcohol Oxidoreductases - chemistry Alcohol Oxidoreductases - genetics Alcohol Oxidoreductases - metabolism Bacteria Biocatalysts Bioconversion Calcium ions Catalytic Domain Cryoelectron Microscopy Cytochrome E coli Electron microscopy Enzymes Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Genes Gram-negative bacteria Humanities and Social Sciences Metabolism Methane Methane - metabolism Methanol Methanol - metabolism Methanol dehydrogenase Methylotrophic bacteria Models, Molecular Molecular Chaperones - genetics Molecular Chaperones - metabolism Molecular modelling multidisciplinary Oxidation Plasmids PQQ Cofactor - metabolism Proteins Pyrroloquinoline quinone Quinones Science Science (multidisciplinary) Transcription factors
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