Assessment of oral toxicity of Moringa oleifera Lam aqueous extract and its effect on gout induced in a murine model

• Published in: Veterinary World 2024-07, Vol.17 (7), p.1449-1458
• Main Authors: Palomino-Pacheco, Miriam, Rojas-Armas, Juan Pedro, Ortiz-Sánchez, José Manuel, Arroyo-Acevedo, Jorge Luis, Justil-Guerrero, Hugo Jesús, Martínez-Heredia, Jaime Teodocio
• Format: Article
• Language: English
• Subjects: Acetic acid; Analysis; Care and treatment; Ethylenediaminetetraacetic acid; extract; Gout; Medicine, Botanic; Medicine, Herbal; moringa oleifera; murine; Organic acids; Pain; toxicity
• ISSN: 0972-8988; 2231-0916
• DOI: 10.14202/vetworld.2024.1449-1458

Although widely employed in traditional remedies globally, the safety and efficacy of remain inadequately documented through scientific research. This study evaluated the oral toxicity of leaf aqueous extract (MoAE) and its impact on gout-induced rats. 2000 mg/kg was given in a single dose during the acute oral toxicity test, while 100 mg/kg, 250 mg/kg, and 500 mg/kg were given daily for 28 days in the repeated dose toxicity test. 100 mg/kg, 250 mg/kg, and 500 mg/kg MoAE doses were administered during the assessment of its impact on gout caused by monosodium urate. In the hyperuricemia model induced by oxonic acid, serum uric acid levels were assessed and pain response was measured through acetic acid-induced writhing. In acute oral and 28-day repeated dose tests, no indications of toxicity were detected, while MoAE alleviated ankle joint swelling and reduced serum uric acid concentrations in arthritic rats, causing a significant reduction in acetic acid-induced contortions. No acute oral toxicity or toxicity in 28-day repeated doses was found for MoAE, while it exhibited antiarthritic, antihyperuricemic, and pain-relieving effects in the murine model.