Discriminant Validity of a Single Clinical Question for the Screening of Inactivity in Individuals Living with COPD

• Published in: International journal of chronic obstructive pulmonary disease 2022-01, Vol.17, p.3033-3044
• Main Authors: Ramon, Maria Antonia, Esteban, Cristóbal, Ortega, Francisco, Cebollero, Pilar, Carrascosa, Inés, Martinez-González, Cristina, Sobradillo, Patricia, Soler-Cataluña, Juan José, Miravitlles, Marc, García-Río, Francisco
• Format: Article
• Language: English
• Subjects: Accelerometers; Aged; Body mass index; Chronic obstructive pulmonary disease; Dyspnea; Exercise; Hospitals; Humans; Lung diseases, Obstructive; Normal distribution; Original Research; outcome assessment; Patients; physical activity; Physical fitness; Pulmonary Disease, Chronic Obstructive - diagnosis; Questionnaires; Sociodemographics; Spirometry; validation studies; Values; Variables; Walking
• ISSN: 1178-2005; 1176-9106; 1178-2005
• DOI: 10.2147/COPD.S378758

Quantifying physical activity in chronic obstructive pulmonary disease (COPD) with questionnaires and activity monitors in clinical practice is challenging. The aim of the present study was to analyse the discriminant validity of a single clinical question for the screening of inactive individuals living with COPD. A multicentre study was carried out in stable COPD individuals both in primary and tertiary care. Patients wore the accelerometer for 8 days and then answered 5 physical activity questions developed for the study, referring to the week in which their physical activity was monitored. Receiver operating characteristic (ROC) curve analysis with physical activity level (PAL) as the gold standard reference was used to determine the best cut-off point for each of the 5 clinical physical activity questions tested. A total of 86 COPD participants were analysed (males 68.6%; mean (SD) age 66.6 (8.5) years; FEV 50.9 (17.3)% predicted; mean of 7305 (3906) steps/day). Forty-two (48.8%) participants were considered physically inactive (PAL ≤1.69). Answers to 4 out of 5 questions significantly differed in active vs inactive patients. The Kappa index and ROC curves showed that the answer to the question "On average, how many minutes per day do you walk briskly?" had the best discriminative capacity for inactivity, with an area under the curve (AUC) (95% Confidence interval (CI)) of 0.73 (0.63-0.84) and 30 min/day was identified as the best cut-off value (sensitivity (95% CI): 0.75 (0.60-0.87); specificity: 0.76 (0.61-0.88)). The present results indicate that self-reported brisk walk time lower than 30 min/day may be a valid tool for the screening of inactivity in individuals living with COPD in routine care, if more detailed physical activity measures are not feasible.