Computed tomography lung parenchymal descriptions in routine radiological reporting have diagnostic and prognostic utility in patients with idiopathic pulmonary arterial hypertension and pulmonary hypertension associated with lung disease

Patients with pulmonary hypertension (PH) and lung disease may pose a diagnostic dilemma between idiopathic pulmonary arterial hypertension (IPAH) and PH associated with lung disease (PH-CLD). The prognostic impact of common computed tomography (CT) parenchymal features is unknown. 660 IPAH and PH-C...

Full description

Saved in:
Bibliographic Details
Published in:ERJ open research 2022-01, Vol.8 (1), p.549
Main Authors: Dwivedi, Krit, Condliffe, Robin, Sharkey, Michael, Lewis, Robert, Alabed, Samer, Rajaram, Smitha, Hill, Catherine, Saunders, Laura, Metherall, Peter, Alandejani, Faisal, Alkhanfar, Dheyaa, Wild, Jim M, Lu, Haiping, Kiely, David G, Swift, Andrew J
Format: Article
Language:English
Subjects:
Original
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Patients with pulmonary hypertension (PH) and lung disease may pose a diagnostic dilemma between idiopathic pulmonary arterial hypertension (IPAH) and PH associated with lung disease (PH-CLD). The prognostic impact of common computed tomography (CT) parenchymal features is unknown. 660 IPAH and PH-CLD patients assessed between 2001 and 2019 were included. Reports for all CT scans 1 year prior to diagnosis were analysed for common lung parenchymal patterns. Cox regression and Kaplan-Meier analysis were performed. At univariate analysis of the whole cohort, centrilobular ground-glass (CGG) changes (hazard ratio, HR 0.29) and ground-glass opacification (HR 0.53) predicted improved survival, while honeycombing (HR 2.79), emphysema (HR 2.09) and fibrosis (HR 2.38) predicted worse survival (all p
ISSN:2312-0541
2312-0541
DOI:10.1183/23120541.00549-2021