Embryonic-maternal cross-talk via exosomes: potential implications

A myriad of locally produced factors into the microenvironment of the reproductive tract is regulated, not one-way but rather, through embryonic-maternal cross-talk. In this mini-review, we focused on the exosomes, which are cell-derived vesicles of 30-100 nm in diameter, as a communicating language...

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Bibliographic Details
Published in:Stem cells and cloning 2015-01, Vol.8 (default), p.103-107
Main Authors: Saadeldin, Islam M, Oh, Hyun Ju, Lee, Byeong Chun
Format: Article
Language:English
Subjects:
Analysis
Cell adhesion & migration
Cell interaction
Communication
Deoxyribonucleic acid
DNA
Expert Opinion
Fetuses
Gene expression
Medical prognosis
MicroRNAs
Placenta
Pregnancy
Proteins
Stem cells
Veterinary medicine
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Summary:A myriad of locally produced factors into the microenvironment of the reproductive tract is regulated, not one-way but rather, through embryonic-maternal cross-talk. In this mini-review, we focused on the exosomes, which are cell-derived vesicles of 30-100 nm in diameter, as a communicating language facilitating this dialog. These nanovesicles are secreted from pre-implantation embryos, oviduct epithelium, and endometrium as well as from the placenta, and contain proteins, messenger RNA (mRNA), microRNA, and DNA cargoes, and have pleiotropic effects on both embryonic and maternal environments. A better understanding of the molecular mechanisms mediating this cross-talk will lead to the development of new regulating agents, with novel diagnostic, biological, and therapeutic potential for either supporting or hindering the normal reproductive functions.
ISSN:1178-6957
1178-6957
DOI:10.2147/SCCAA.S84991