Synthesis of 5-azaandrostane-3β, 17β-diol protected at the 17-hydroxyl group

In the present paper, the preparation of 3?-hydroxy-17?-dimethyl-tert-butylsilyloxy- 5-azaandrostane (15) in fourteen steps is described. B-nor-17-oxoandrost- 5-en-3?-yl acetate (1)1,2 was used as the starting material, which was transformed to the key intermediate of the synthesis, B-nor-17?-dimeth...

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Published in:Journal of the Serbian Chemical Society 2004, Vol.69 (11), p.861-869
Main Authors: Pavlovic, Vladimir, Dabovic, Milan, Martinovic, Sasa, Lorenc, Ljubinka, Kalvoda, Jaroslav
Format: Article
Language:English
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3β-hydroxy-17β-dimethyl-tert-butylsilyloxy-5-azaandrostane
5-azasteroids
b-nor-17-oxoandrost-5-en-3-yl acetate
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cited_by cdi_FETCH-LOGICAL-c181p-7cce14b91c0153abd83cac176713403640be343b0253e23734bf87b18955ae303
cites cdi_FETCH-LOGICAL-c181p-7cce14b91c0153abd83cac176713403640be343b0253e23734bf87b18955ae303
container_end_page 869
container_issue 11
container_start_page 861
container_title Journal of the Serbian Chemical Society
container_volume 69
creator Pavlovic, Vladimir
Dabovic, Milan
Martinovic, Sasa
Lorenc, Ljubinka
Kalvoda, Jaroslav
description In the present paper, the preparation of 3?-hydroxy-17?-dimethyl-tert-butylsilyloxy- 5-azaandrostane (15) in fourteen steps is described. B-nor-17-oxoandrost- 5-en-3?-yl acetate (1)1,2 was used as the starting material, which was transformed to the key intermediate of the synthesis, B-nor-17?-dimethyl-tert-butylsilyloxyandrost- 4-en-3?-yl acetate (7). U ovom radu je opisano dobijanje 3?-hidroksi-17?-dimetil-tert-butilsililoksi-5-azaandrostana (15) u 14 faza. Kao polazno jedinjenje upotrebljen je B-nor-17-oksoandrost- 5-en-3?-il-acetat (1) koji je transformisan u kljucni intermedijer sinteze, B-nor-17?-dimetil tert-butilsililoksiandrost-4-en-3?-il-acetat (7).
doi_str_mv 10.2298/JSC0411861P
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subjects 3β-hydroxy-17β-dimethyl-tert-butylsilyloxy-5-azaandrostane
5-azasteroids
b-nor-17-oxoandrost-5-en-3-yl acetate
title Synthesis of 5-azaandrostane-3β, 17β-diol protected at the 17-hydroxyl group
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