Osteoblast response to disordered nanotopography

The ability to influence stem cell differentiation is highly desirable as it would help us improve clinical outcomes for patients in various aspects. Many different techniques to achieve this have previously been investigated. This concise study, however, has focused on the topography on which cells...

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Bibliographic Details
Published in:Journal of tissue engineering 2018-01, Vol.9, p.2041731418784098-2041731418784098
Main Authors: Allan, Christopher, Ker, Andrew, Smith, Carol-Anne, Tsimbouri, Penelope M, Borsoi, Juliana, O’Neill, Stewart, Gadegaard, Nikolaj, Dalby, Matthew J, Dominic Meek, RM
Format: Article
Language:English
Subjects:
Biomedical materials
Bone marrow
Cell differentiation
Cell Engineering at the Micro/Nanoscale – dedicated to Prof Adam Curtis
Differentiation (biology)
Mesenchyme
Metals
Orthopaedic implants
Orthopedics
Osteoblastogenesis
Osteoblasts
Polymers
Soft tissues
Stem cells
Surgical implants
Topography
Transplants & implants
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Summary:The ability to influence stem cell differentiation is highly desirable as it would help us improve clinical outcomes for patients in various aspects. Many different techniques to achieve this have previously been investigated. This concise study, however, has focused on the topography on which cells grow. Current uncemented orthopaedic implants can fail if the implant fails to bind to the surrounding bone and, typically, forms a soft tissue interface which reduces direct bone contact. Here, we look at the effect of a previously reported nanotopography that utilises nanodisorder to influence mesenchymal stromal cell (as may be found in the bone marrow) differentiation towards bone and to also exert this effect on mature osteoblasts (as may be found in the bone). As topography is a physical technique, it can be envisaged for use in a range of materials such as polymers and metals used in the manufacture of orthopaedic implants.
ISSN:2041-7314
2041-7314
DOI:10.1177/2041731418784098