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Utility of Procalcitonin (PCT) and Mid regional pro-Adrenomedullin (MR-proADM) in risk stratification of critically ill febrile patients in Emergency Department (ED). A comparison with APACHE II score
The aim of our study was to evaluate the prognostic value of MR-proADM and PCT levels in febrile patients in the ED in comparison with a disease severity index score, the APACHE II score. We also evaluated the ability of MR-proADM and PCT to predict hospitalization. This was an observational, multic...
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| Published in: | BMC infectious diseases 2012-08, Vol.12 (1), p.184-184, Article 184 |
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| creator | Travaglino, Francesco De Berardinis, Benedetta Magrini, Laura Bongiovanni, Cristina Candelli, Marcello Silveri, Nicolò Gentiloni Legramante, Jacopo Galante, Alberto Salerno, Gerardo Cardelli, Patrizia Di Somma, Salvatore |
| description | The aim of our study was to evaluate the prognostic value of MR-proADM and PCT levels in febrile patients in the ED in comparison with a disease severity index score, the APACHE II score. We also evaluated the ability of MR-proADM and PCT to predict hospitalization.
This was an observational, multicentric study. We enrolled 128 patients referred to the ED with high fever and a suspicion of severe infection such as sepsis, lower respiratory tract infections, urinary tract infections, gastrointestinal infections, soft tissue infections, central nervous system infections, or osteomyelitis. The APACHE II score was calculated for each patient.
MR-proADM median values in controls were 0.5 nmol/l as compared with 0.85 nmol/l in patients (P |
| doi_str_mv | 10.1186/1471-2334-12-184 |
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| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_86b7fcbd393c438a8ffd4fdc164aef34</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_86b7fcbd393c438a8ffd4fdc164aef34</doaj_id><sourcerecordid>2772080431</sourcerecordid><originalsourceid>FETCH-LOGICAL-b550t-c05ddcdeba4ca3f07877bca68ee2c8d15a3b28caaa6660b16d5ff7ad10dc5f773</originalsourceid><addsrcrecordid>eNp1kk1vEzEQhlcIREvhzglZ4pIctti7Xtu5IK2SlEZqRITas-X1R-rgXaf2BpR_yM-ql5SoQXCxPTPvPBqP3ix7j-AlQox8QpiivChLnKMiRwy_yM6PqZfP3mfZmxg3ECLKisnr7KwoGMWQ0PPs111vne33wBuwCl4KJ23vO9uB0Wp6OwaiU2BpFQh6bX0nHNgGn9cq6M63Wu2cG5TLb3lK17PlGKQw2PgdxD6I3hor0-m7gS6D7VPo3B5Y54DRTbBOg20S6K6PQ-e81WGtO7kHM70VoW9TAYzms_ElqIH0bcrZmGg_bX8P6lU9vZ6DxQJE6YN-m70ywkX97um-yO6u5rfT6_zm65fFtL7Jm6qCfS5hpZRUuhFYitJAyihtpCBM60IyhSpRNgWTQghCCGwQUZUxVCgElawMpeVFtjhwlRcbvg22FWHPvbD8d8KHNU-TW-k0Z6ShRjaqnJQSl0wwYxQ2SiKChTYlTqzPB9Z216RtyvTdINwJ9LTS2Xu-9j94iTElGCbA9ABorP8P4LSSlsgHV_DBFRwVPJkmUUZPYwT_sNOx562NUjsnOu13kSNIJgXEDJIk_fiXdON3IfliUDFI087wJKngQSWDjzFoc5wIQT4Y918zfHi-imPDH6eWj8IL7II</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1080766049</pqid></control><display><type>article</type><title>Utility of Procalcitonin (PCT) and Mid regional pro-Adrenomedullin (MR-proADM) in risk stratification of critically ill febrile patients in Emergency Department (ED). A comparison with APACHE II score</title><source>Publicly Available Content (ProQuest)</source><source>PubMed Central</source><creator>Travaglino, Francesco ; De Berardinis, Benedetta ; Magrini, Laura ; Bongiovanni, Cristina ; Candelli, Marcello ; Silveri, Nicolò Gentiloni ; Legramante, Jacopo ; Galante, Alberto ; Salerno, Gerardo ; Cardelli, Patrizia ; Di Somma, Salvatore</creator><creatorcontrib>Travaglino, Francesco ; De Berardinis, Benedetta ; Magrini, Laura ; Bongiovanni, Cristina ; Candelli, Marcello ; Silveri, Nicolò Gentiloni ; Legramante, Jacopo ; Galante, Alberto ; Salerno, Gerardo ; Cardelli, Patrizia ; Di Somma, Salvatore</creatorcontrib><description>The aim of our study was to evaluate the prognostic value of MR-proADM and PCT levels in febrile patients in the ED in comparison with a disease severity index score, the APACHE II score. We also evaluated the ability of MR-proADM and PCT to predict hospitalization.
This was an observational, multicentric study. We enrolled 128 patients referred to the ED with high fever and a suspicion of severe infection such as sepsis, lower respiratory tract infections, urinary tract infections, gastrointestinal infections, soft tissue infections, central nervous system infections, or osteomyelitis. The APACHE II score was calculated for each patient.
MR-proADM median values in controls were 0.5 nmol/l as compared with 0.85 nmol/l in patients (P < 0.0001), while PCT values in controls were 0.06 ng/ml versus 0.56 ng/ml in patients (P < 0.0001). In all patients there was a statistically significant stepwise increase in MR-proADM levels in accordance with PCT values (P < 0.0001). MR-proADM and PCT levels were significantly increased in accordance with the Apache II quartiles (P < 0.0001 and P = 0.0012 respectively).In the respiratory infections, urinary infections, and sepsis-septic shock groups we found a correlation between the Apache II and MR-proADM respectively and MR-proADM and PCT respectively. We evaluated the ability of MR-proADM and PCT to predict hospitalization in patients admitted to our emergency departments complaining of fever. MR-proADM alone had an AUC of 0.694, while PCT alone had an AUC of 0.763. The combined use of PCT and MR-proADM instead showed an AUC of 0.79.
The present study highlights the way in which MR-proADM and PCT may be helpful to the febrile patient's care in the ED. Our data support the prognostic role of MR-proADM and PCT in that setting, as demonstrated by the correlation with the APACHE II score. The combined use of the two biomarkers can predict a subsequent hospitalization of febrile patients. The rational use of these two molecules could lead to several advantages, such as faster diagnosis, more accurate risk stratification, and optimization of the treatment, with consequent benefit to the patient and considerably reduced costs.</description><identifier>ISSN: 1471-2334</identifier><identifier>EISSN: 1471-2334</identifier><identifier>DOI: 10.1186/1471-2334-12-184</identifier><identifier>PMID: 22874067</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Adolescent ; Adrenomedullin - blood ; Adult ; Aged ; Aged, 80 and over ; Amino acids ; APACHE ; APACHE II score ; Bacterial infections ; Biomarkers ; Calcitonin - blood ; Calcitonin Gene-Related Peptide ; Critical care ; Critical Illness ; Emergency medical care ; Emergency Medical Services - methods ; Ethics ; Female ; Fever ; Fever - diagnosis ; Hospitals ; Humans ; Infections ; Male ; Medicine ; Mid regional pro-Adrenomedullin ; Middle Aged ; Mortality ; Patients ; Peptide Fragments - blood ; Peptides ; Procalcitonin ; Prognosis ; Protein Precursors - blood ; Sepsis ; Severity of Illness Index ; Software ; Statistical analysis ; Viral infections ; Young Adult</subject><ispartof>BMC infectious diseases, 2012-08, Vol.12 (1), p.184-184, Article 184</ispartof><rights>2012 Travaglino et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright ©2012 Travaglino et al.; licensee BioMed Central Ltd. 2012 Travaglino et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b550t-c05ddcdeba4ca3f07877bca68ee2c8d15a3b28caaa6660b16d5ff7ad10dc5f773</citedby><cites>FETCH-LOGICAL-b550t-c05ddcdeba4ca3f07877bca68ee2c8d15a3b28caaa6660b16d5ff7ad10dc5f773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447640/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1080766049?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22874067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Travaglino, Francesco</creatorcontrib><creatorcontrib>De Berardinis, Benedetta</creatorcontrib><creatorcontrib>Magrini, Laura</creatorcontrib><creatorcontrib>Bongiovanni, Cristina</creatorcontrib><creatorcontrib>Candelli, Marcello</creatorcontrib><creatorcontrib>Silveri, Nicolò Gentiloni</creatorcontrib><creatorcontrib>Legramante, Jacopo</creatorcontrib><creatorcontrib>Galante, Alberto</creatorcontrib><creatorcontrib>Salerno, Gerardo</creatorcontrib><creatorcontrib>Cardelli, Patrizia</creatorcontrib><creatorcontrib>Di Somma, Salvatore</creatorcontrib><title>Utility of Procalcitonin (PCT) and Mid regional pro-Adrenomedullin (MR-proADM) in risk stratification of critically ill febrile patients in Emergency Department (ED). A comparison with APACHE II score</title><title>BMC infectious diseases</title><addtitle>BMC Infect Dis</addtitle><description>The aim of our study was to evaluate the prognostic value of MR-proADM and PCT levels in febrile patients in the ED in comparison with a disease severity index score, the APACHE II score. We also evaluated the ability of MR-proADM and PCT to predict hospitalization.
This was an observational, multicentric study. We enrolled 128 patients referred to the ED with high fever and a suspicion of severe infection such as sepsis, lower respiratory tract infections, urinary tract infections, gastrointestinal infections, soft tissue infections, central nervous system infections, or osteomyelitis. The APACHE II score was calculated for each patient.
MR-proADM median values in controls were 0.5 nmol/l as compared with 0.85 nmol/l in patients (P < 0.0001), while PCT values in controls were 0.06 ng/ml versus 0.56 ng/ml in patients (P < 0.0001). In all patients there was a statistically significant stepwise increase in MR-proADM levels in accordance with PCT values (P < 0.0001). MR-proADM and PCT levels were significantly increased in accordance with the Apache II quartiles (P < 0.0001 and P = 0.0012 respectively).In the respiratory infections, urinary infections, and sepsis-septic shock groups we found a correlation between the Apache II and MR-proADM respectively and MR-proADM and PCT respectively. We evaluated the ability of MR-proADM and PCT to predict hospitalization in patients admitted to our emergency departments complaining of fever. MR-proADM alone had an AUC of 0.694, while PCT alone had an AUC of 0.763. The combined use of PCT and MR-proADM instead showed an AUC of 0.79.
The present study highlights the way in which MR-proADM and PCT may be helpful to the febrile patient's care in the ED. Our data support the prognostic role of MR-proADM and PCT in that setting, as demonstrated by the correlation with the APACHE II score. The combined use of the two biomarkers can predict a subsequent hospitalization of febrile patients. The rational use of these two molecules could lead to several advantages, such as faster diagnosis, more accurate risk stratification, and optimization of the treatment, with consequent benefit to the patient and considerably reduced costs.</description><subject>Adolescent</subject><subject>Adrenomedullin - blood</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amino acids</subject><subject>APACHE</subject><subject>APACHE II score</subject><subject>Bacterial infections</subject><subject>Biomarkers</subject><subject>Calcitonin - blood</subject><subject>Calcitonin Gene-Related Peptide</subject><subject>Critical care</subject><subject>Critical Illness</subject><subject>Emergency medical care</subject><subject>Emergency Medical Services - methods</subject><subject>Ethics</subject><subject>Female</subject><subject>Fever</subject><subject>Fever - diagnosis</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infections</subject><subject>Male</subject><subject>Medicine</subject><subject>Mid regional pro-Adrenomedullin</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Patients</subject><subject>Peptide Fragments - blood</subject><subject>Peptides</subject><subject>Procalcitonin</subject><subject>Prognosis</subject><subject>Protein Precursors - blood</subject><subject>Sepsis</subject><subject>Severity of Illness Index</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Viral infections</subject><subject>Young Adult</subject><issn>1471-2334</issn><issn>1471-2334</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp1kk1vEzEQhlcIREvhzglZ4pIctti7Xtu5IK2SlEZqRITas-X1R-rgXaf2BpR_yM-ql5SoQXCxPTPvPBqP3ix7j-AlQox8QpiivChLnKMiRwy_yM6PqZfP3mfZmxg3ECLKisnr7KwoGMWQ0PPs111vne33wBuwCl4KJ23vO9uB0Wp6OwaiU2BpFQh6bX0nHNgGn9cq6M63Wu2cG5TLb3lK17PlGKQw2PgdxD6I3hor0-m7gS6D7VPo3B5Y54DRTbBOg20S6K6PQ-e81WGtO7kHM70VoW9TAYzms_ElqIH0bcrZmGg_bX8P6lU9vZ6DxQJE6YN-m70ywkX97um-yO6u5rfT6_zm65fFtL7Jm6qCfS5hpZRUuhFYitJAyihtpCBM60IyhSpRNgWTQghCCGwQUZUxVCgElawMpeVFtjhwlRcbvg22FWHPvbD8d8KHNU-TW-k0Z6ShRjaqnJQSl0wwYxQ2SiKChTYlTqzPB9Z216RtyvTdINwJ9LTS2Xu-9j94iTElGCbA9ABorP8P4LSSlsgHV_DBFRwVPJkmUUZPYwT_sNOx562NUjsnOu13kSNIJgXEDJIk_fiXdON3IfliUDFI087wJKngQSWDjzFoc5wIQT4Y918zfHi-imPDH6eWj8IL7II</recordid><startdate>20120808</startdate><enddate>20120808</enddate><creator>Travaglino, Francesco</creator><creator>De Berardinis, Benedetta</creator><creator>Magrini, Laura</creator><creator>Bongiovanni, Cristina</creator><creator>Candelli, Marcello</creator><creator>Silveri, Nicolò Gentiloni</creator><creator>Legramante, Jacopo</creator><creator>Galante, Alberto</creator><creator>Salerno, Gerardo</creator><creator>Cardelli, Patrizia</creator><creator>Di Somma, Salvatore</creator><general>BioMed Central</general><general>BioMed Central Ltd</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T2</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120808</creationdate><title>Utility of Procalcitonin (PCT) and Mid regional pro-Adrenomedullin (MR-proADM) in risk stratification of critically ill febrile patients in Emergency Department (ED). A comparison with APACHE II score</title><author>Travaglino, Francesco ; De Berardinis, Benedetta ; Magrini, Laura ; Bongiovanni, Cristina ; Candelli, Marcello ; Silveri, Nicolò Gentiloni ; Legramante, Jacopo ; Galante, Alberto ; Salerno, Gerardo ; Cardelli, Patrizia ; Di Somma, Salvatore</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b550t-c05ddcdeba4ca3f07877bca68ee2c8d15a3b28caaa6660b16d5ff7ad10dc5f773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adrenomedullin - blood</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amino acids</topic><topic>APACHE</topic><topic>APACHE II score</topic><topic>Bacterial infections</topic><topic>Biomarkers</topic><topic>Calcitonin - blood</topic><topic>Calcitonin Gene-Related Peptide</topic><topic>Critical care</topic><topic>Critical Illness</topic><topic>Emergency medical care</topic><topic>Emergency Medical Services - methods</topic><topic>Ethics</topic><topic>Female</topic><topic>Fever</topic><topic>Fever - diagnosis</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infections</topic><topic>Male</topic><topic>Medicine</topic><topic>Mid regional pro-Adrenomedullin</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Patients</topic><topic>Peptide Fragments - blood</topic><topic>Peptides</topic><topic>Procalcitonin</topic><topic>Prognosis</topic><topic>Protein Precursors - blood</topic><topic>Sepsis</topic><topic>Severity of Illness Index</topic><topic>Software</topic><topic>Statistical analysis</topic><topic>Viral infections</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Travaglino, Francesco</creatorcontrib><creatorcontrib>De Berardinis, Benedetta</creatorcontrib><creatorcontrib>Magrini, Laura</creatorcontrib><creatorcontrib>Bongiovanni, Cristina</creatorcontrib><creatorcontrib>Candelli, Marcello</creatorcontrib><creatorcontrib>Silveri, Nicolò Gentiloni</creatorcontrib><creatorcontrib>Legramante, Jacopo</creatorcontrib><creatorcontrib>Galante, Alberto</creatorcontrib><creatorcontrib>Salerno, Gerardo</creatorcontrib><creatorcontrib>Cardelli, Patrizia</creatorcontrib><creatorcontrib>Di Somma, Salvatore</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>BMC infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Travaglino, Francesco</au><au>De Berardinis, Benedetta</au><au>Magrini, Laura</au><au>Bongiovanni, Cristina</au><au>Candelli, Marcello</au><au>Silveri, Nicolò Gentiloni</au><au>Legramante, Jacopo</au><au>Galante, Alberto</au><au>Salerno, Gerardo</au><au>Cardelli, Patrizia</au><au>Di Somma, Salvatore</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utility of Procalcitonin (PCT) and Mid regional pro-Adrenomedullin (MR-proADM) in risk stratification of critically ill febrile patients in Emergency Department (ED). A comparison with APACHE II score</atitle><jtitle>BMC infectious diseases</jtitle><addtitle>BMC Infect Dis</addtitle><date>2012-08-08</date><risdate>2012</risdate><volume>12</volume><issue>1</issue><spage>184</spage><epage>184</epage><pages>184-184</pages><artnum>184</artnum><issn>1471-2334</issn><eissn>1471-2334</eissn><abstract>The aim of our study was to evaluate the prognostic value of MR-proADM and PCT levels in febrile patients in the ED in comparison with a disease severity index score, the APACHE II score. We also evaluated the ability of MR-proADM and PCT to predict hospitalization.
This was an observational, multicentric study. We enrolled 128 patients referred to the ED with high fever and a suspicion of severe infection such as sepsis, lower respiratory tract infections, urinary tract infections, gastrointestinal infections, soft tissue infections, central nervous system infections, or osteomyelitis. The APACHE II score was calculated for each patient.
MR-proADM median values in controls were 0.5 nmol/l as compared with 0.85 nmol/l in patients (P < 0.0001), while PCT values in controls were 0.06 ng/ml versus 0.56 ng/ml in patients (P < 0.0001). In all patients there was a statistically significant stepwise increase in MR-proADM levels in accordance with PCT values (P < 0.0001). MR-proADM and PCT levels were significantly increased in accordance with the Apache II quartiles (P < 0.0001 and P = 0.0012 respectively).In the respiratory infections, urinary infections, and sepsis-septic shock groups we found a correlation between the Apache II and MR-proADM respectively and MR-proADM and PCT respectively. We evaluated the ability of MR-proADM and PCT to predict hospitalization in patients admitted to our emergency departments complaining of fever. MR-proADM alone had an AUC of 0.694, while PCT alone had an AUC of 0.763. The combined use of PCT and MR-proADM instead showed an AUC of 0.79.
The present study highlights the way in which MR-proADM and PCT may be helpful to the febrile patient's care in the ED. Our data support the prognostic role of MR-proADM and PCT in that setting, as demonstrated by the correlation with the APACHE II score. The combined use of the two biomarkers can predict a subsequent hospitalization of febrile patients. The rational use of these two molecules could lead to several advantages, such as faster diagnosis, more accurate risk stratification, and optimization of the treatment, with consequent benefit to the patient and considerably reduced costs.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>22874067</pmid><doi>10.1186/1471-2334-12-184</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMC infectious diseases, 2012-08, Vol.12 (1), p.184-184, Article 184 |
| issn | 1471-2334 1471-2334 |
| language | eng |
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| source | Publicly Available Content (ProQuest); PubMed Central |
| subjects | Adolescent Adrenomedullin - blood Adult Aged Aged, 80 and over Amino acids APACHE APACHE II score Bacterial infections Biomarkers Calcitonin - blood Calcitonin Gene-Related Peptide Critical care Critical Illness Emergency medical care Emergency Medical Services - methods Ethics Female Fever Fever - diagnosis Hospitals Humans Infections Male Medicine Mid regional pro-Adrenomedullin Middle Aged Mortality Patients Peptide Fragments - blood Peptides Procalcitonin Prognosis Protein Precursors - blood Sepsis Severity of Illness Index Software Statistical analysis Viral infections Young Adult |
| title | Utility of Procalcitonin (PCT) and Mid regional pro-Adrenomedullin (MR-proADM) in risk stratification of critically ill febrile patients in Emergency Department (ED). A comparison with APACHE II score |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T20%3A41%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Utility%20of%20Procalcitonin%20(PCT)%20and%20Mid%20regional%20pro-Adrenomedullin%20(MR-proADM)%20in%20risk%20stratification%20of%20critically%20ill%20febrile%20patients%20in%20Emergency%20Department%20(ED).%20A%20comparison%20with%20APACHE%20II%20score&rft.jtitle=BMC%20infectious%20diseases&rft.au=Travaglino,%20Francesco&rft.date=2012-08-08&rft.volume=12&rft.issue=1&rft.spage=184&rft.epage=184&rft.pages=184-184&rft.artnum=184&rft.issn=1471-2334&rft.eissn=1471-2334&rft_id=info:doi/10.1186/1471-2334-12-184&rft_dat=%3Cproquest_doaj_%3E2772080431%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-b550t-c05ddcdeba4ca3f07877bca68ee2c8d15a3b28caaa6660b16d5ff7ad10dc5f773%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1080766049&rft_id=info:pmid/22874067&rfr_iscdi=true |