Admission Glucose Levels and Associated Risk for Heart Failure After Myocardial Infarction in Patients Without Diabetes

Background Dysglycemia at acute myocardial infarction (AMI) is common and is associated with mortality. Information on other outcomes is less well explored in patients without diabetes in a long-term perspective. We aimed to explore the relationship between admission glucose level and long-term outc...

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Bibliographic Details
Published in:Journal of the American Heart Association 2021-11, Vol.10 (22), p.e022667-e022667
Main Authors: Ritsinger, Viveca, Hagström, Emil, Lagerqvist, Bo, Norhammar, Anna
Format: Article
Language:English
Subjects:
admission glucose
Blood Glucose
Diabetes Mellitus - diagnosis
Diabetes Mellitus - epidemiology
heart failure
Heart Failure - diagnosis
Heart Failure - epidemiology
Hospitalization
Humans
Medicin och hälsovetenskap
myocardial infarction
Myocardial Infarction - diagnosis
Myocardial Infarction - epidemiology
Original Research
Prognosis
Registries
Renal Insufficiency
Risk Factors
Stroke
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Summary:Background Dysglycemia at acute myocardial infarction (AMI) is common and is associated with mortality. Information on other outcomes is less well explored in patients without diabetes in a long-term perspective. We aimed to explore the relationship between admission glucose level and long-term outcomes in patients with AMI without diabetes in a nationwide setting. Methods and Results Patients without diabetes (n=45 468) with AMI registered in SWEDEHEART (Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies) and admission glucose ≤11 mmol/L (≤198 mg/dL) were followed for outcomes (AMI, heart failure, stroke, renal failure, and death) between 2012 and 2017 (mean follow-up time 3.3±1.7 years). The association between categorized glucose levels and outcomes was assessed in adjusted Cox proportional hazards regression analyses (glucose levels 4.0-6.0 mmol/L [72-109 mg/dL] as reference). Further nonfatal complications and their associated mortality were explored (patients without events served as a reference). A glucose level of 7.8-11.0 mmol/L (140-198 mg/dL) was associated with hospitalization for heart failure (hazard ratio [HR] 1.40 [95% CI, 1.30-1.51],
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.121.022667