Loading…
Change in levothyroxine requirements after bariatric surgery in patients with hypothyroidism
This study aims to evaluate the need to modify the total and weight-adjusted doses of levothyroxine after bariatric surgery, identify predictors, and assess the influence of the weight loss on the levothyroxine requirements. A retrospective study in patients with treated hypothyroidism that underwen...
Saved in:
| Published in: | Endocrine regulations (Bratislava) 2022-04, Vol.56 (2), p.81-86 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c3221-e1fa5a6135ce773dfb8f24433aff06f48fdf8d1d6f9c9434bb7657fde26293463 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c3221-e1fa5a6135ce773dfb8f24433aff06f48fdf8d1d6f9c9434bb7657fde26293463 |
| container_end_page | 86 |
| container_issue | 2 |
| container_start_page | 81 |
| container_title | Endocrine regulations (Bratislava) |
| container_volume | 56 |
| creator | Garcia-Moreno, Rosa Maria Cos-Blanco, Ana Isabel Calvo-Vinuela, Isabel Zapatero-Larrauri, Miriam Herranz, Lucrecia |
| description | This study aims to evaluate the need to modify the total and weight-adjusted doses of levothyroxine after bariatric surgery, identify predictors, and assess the influence of the weight loss on the levothyroxine requirements.
A retrospective study in patients with treated hypothyroidism that underwent bariatric surgery. The modification of the levothyroxine dose and its association with the weight loss and other potential predictors were evaluated at 6, 12, and 24 months post-surgery.
Among the 63 patients included, 82.54% needed an adjustment of levothyroxine dose during the follow-up. The total weekly dose of levothyroxine (µg) decreased post-surgery at 6 months (β= −49.1; 95%CI-93.7 to −4.5; p=0.031) and 12 months (β=−54.9; 95%CI-102 to −7.8; p=0.022), but did not significantly change at 24 months (p=0.114). The weekly weight-adjusted dose (µg/k) increased at 6 months (β=1.37; 95%CI 0.91 to 1.83; p |
| doi_str_mv | 10.2478/enr-2022-0009 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_876f28d69d734af89517b4a31a7c4a9c</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_876f28d69d734af89517b4a31a7c4a9c</doaj_id><sourcerecordid>2658229143</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3221-e1fa5a6135ce773dfb8f24433aff06f48fdf8d1d6f9c9434bb7657fde26293463</originalsourceid><addsrcrecordid>eNptkU1rFDEYgIMotq4evcqAFy-j-f7wJouthYIXvQkhM3mzm2U-tslM6_x7s51aRTwlhCdP3vAg9Jrg95Qr_QGGVFNMaY0xNk_QOWFM1phR8_Sv_Rl6kfMBY6qFls_RGRNcG8zVOfqx3bthB1Ucqg5ux2m_pPFnHKBKcDPHBD0MU65cmCBVjUvRTSm2VZ7TDtJyunV0U7xn7uK0r_bLcXVEH3P_Ej0Lrsvw6mHdoO8Xn79tv9TXXy-vtp-u65ZRSmogwQknCRMtKMV8aHSgnDPmQsAycB180J54GUxrOONNo6RQwQOV1DAu2QZdrV4_uoM9pti7tNjRRXt_MKaddWmKbQdWKxmo9tJ4xbgL2giiGu4YcarlzrTF9W51HdN4M0OebB9zC13nBhjnbKkUmlJDyngb9PYf9DDOaSg_tYwIKSQhhhaqXqk2jTknCI8DEmxPCW1JaE8J7Slh4d88WOemB_9I_25WgI8rcOe6ksXDLs1L2fx5_b9iIakm7BccqasV</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3156561192</pqid></control><display><type>article</type><title>Change in levothyroxine requirements after bariatric surgery in patients with hypothyroidism</title><source>DOAJ Directory of Open Access Journals</source><creator>Garcia-Moreno, Rosa Maria ; Cos-Blanco, Ana Isabel ; Calvo-Vinuela, Isabel ; Zapatero-Larrauri, Miriam ; Herranz, Lucrecia</creator><creatorcontrib>Garcia-Moreno, Rosa Maria ; Cos-Blanco, Ana Isabel ; Calvo-Vinuela, Isabel ; Zapatero-Larrauri, Miriam ; Herranz, Lucrecia</creatorcontrib><description>This study aims to evaluate the need to modify the total and weight-adjusted doses of levothyroxine after bariatric surgery, identify predictors, and assess the influence of the weight loss on the levothyroxine requirements.
A retrospective study in patients with treated hypothyroidism that underwent bariatric surgery. The modification of the levothyroxine dose and its association with the weight loss and other potential predictors were evaluated at 6, 12, and 24 months post-surgery.
Among the 63 patients included, 82.54% needed an adjustment of levothyroxine dose during the follow-up. The total weekly dose of levothyroxine (µg) decreased post-surgery at 6 months (β= −49.1; 95%CI-93.7 to −4.5; p=0.031) and 12 months (β=−54.9; 95%CI-102 to −7.8; p=0.022), but did not significantly change at 24 months (p=0.114). The weekly weight-adjusted dose (µg/k) increased at 6 months (β=1.37; 95%CI 0.91 to 1.83; p<0.001), 12 months (β=2.05; 95%CI 1.43 to 2.67; p<0.001), and 24 months (β=2.52; 95%CI 1.74 to 3.30; p<0.001). The weight loss showed association with the weight-adjusted dose (OR=1.07; 95%CI 1.02 to 1.12; p=0.004), but not the total dose (p=0.320).
This study shows a significant decrease in the total dose of levothyroxine requirements change after bariatric surgery during the first year of the follow-up and an increase in the weight-adjusted dose over the first two years. No predictors of modification of the total dose of levothyroxine were identified.</description><identifier>ISSN: 1336-0329</identifier><identifier>ISSN: 1210-0668</identifier><identifier>EISSN: 1336-0329</identifier><identifier>DOI: 10.2478/enr-2022-0009</identifier><identifier>PMID: 35489047</identifier><language>eng</language><publisher>Germany: Sciendo</publisher><subject>Bariatric Surgery ; Gastrointestinal surgery ; Humans ; Hypothyroidism ; Hypothyroidism - drug therapy ; levothyroxine ; Retrospective Studies ; Thyroxine - therapeutic use ; Weight Loss</subject><ispartof>Endocrine regulations (Bratislava), 2022-04, Vol.56 (2), p.81-86</ispartof><rights>2022 Rosa Maria Garcia-Moreno et al., published by Sciendo.</rights><rights>2022. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3221-e1fa5a6135ce773dfb8f24433aff06f48fdf8d1d6f9c9434bb7657fde26293463</citedby><cites>FETCH-LOGICAL-c3221-e1fa5a6135ce773dfb8f24433aff06f48fdf8d1d6f9c9434bb7657fde26293463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,2095,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35489047$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia-Moreno, Rosa Maria</creatorcontrib><creatorcontrib>Cos-Blanco, Ana Isabel</creatorcontrib><creatorcontrib>Calvo-Vinuela, Isabel</creatorcontrib><creatorcontrib>Zapatero-Larrauri, Miriam</creatorcontrib><creatorcontrib>Herranz, Lucrecia</creatorcontrib><title>Change in levothyroxine requirements after bariatric surgery in patients with hypothyroidism</title><title>Endocrine regulations (Bratislava)</title><addtitle>Endocr Regul</addtitle><description>This study aims to evaluate the need to modify the total and weight-adjusted doses of levothyroxine after bariatric surgery, identify predictors, and assess the influence of the weight loss on the levothyroxine requirements.
A retrospective study in patients with treated hypothyroidism that underwent bariatric surgery. The modification of the levothyroxine dose and its association with the weight loss and other potential predictors were evaluated at 6, 12, and 24 months post-surgery.
Among the 63 patients included, 82.54% needed an adjustment of levothyroxine dose during the follow-up. The total weekly dose of levothyroxine (µg) decreased post-surgery at 6 months (β= −49.1; 95%CI-93.7 to −4.5; p=0.031) and 12 months (β=−54.9; 95%CI-102 to −7.8; p=0.022), but did not significantly change at 24 months (p=0.114). The weekly weight-adjusted dose (µg/k) increased at 6 months (β=1.37; 95%CI 0.91 to 1.83; p<0.001), 12 months (β=2.05; 95%CI 1.43 to 2.67; p<0.001), and 24 months (β=2.52; 95%CI 1.74 to 3.30; p<0.001). The weight loss showed association with the weight-adjusted dose (OR=1.07; 95%CI 1.02 to 1.12; p=0.004), but not the total dose (p=0.320).
This study shows a significant decrease in the total dose of levothyroxine requirements change after bariatric surgery during the first year of the follow-up and an increase in the weight-adjusted dose over the first two years. No predictors of modification of the total dose of levothyroxine were identified.</description><subject>Bariatric Surgery</subject><subject>Gastrointestinal surgery</subject><subject>Humans</subject><subject>Hypothyroidism</subject><subject>Hypothyroidism - drug therapy</subject><subject>levothyroxine</subject><subject>Retrospective Studies</subject><subject>Thyroxine - therapeutic use</subject><subject>Weight Loss</subject><issn>1336-0329</issn><issn>1210-0668</issn><issn>1336-0329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkU1rFDEYgIMotq4evcqAFy-j-f7wJouthYIXvQkhM3mzm2U-tslM6_x7s51aRTwlhCdP3vAg9Jrg95Qr_QGGVFNMaY0xNk_QOWFM1phR8_Sv_Rl6kfMBY6qFls_RGRNcG8zVOfqx3bthB1Ucqg5ux2m_pPFnHKBKcDPHBD0MU65cmCBVjUvRTSm2VZ7TDtJyunV0U7xn7uK0r_bLcXVEH3P_Ej0Lrsvw6mHdoO8Xn79tv9TXXy-vtp-u65ZRSmogwQknCRMtKMV8aHSgnDPmQsAycB180J54GUxrOONNo6RQwQOV1DAu2QZdrV4_uoM9pti7tNjRRXt_MKaddWmKbQdWKxmo9tJ4xbgL2giiGu4YcarlzrTF9W51HdN4M0OebB9zC13nBhjnbKkUmlJDyngb9PYf9DDOaSg_tYwIKSQhhhaqXqk2jTknCI8DEmxPCW1JaE8J7Slh4d88WOemB_9I_25WgI8rcOe6ksXDLs1L2fx5_b9iIakm7BccqasV</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Garcia-Moreno, Rosa Maria</creator><creator>Cos-Blanco, Ana Isabel</creator><creator>Calvo-Vinuela, Isabel</creator><creator>Zapatero-Larrauri, Miriam</creator><creator>Herranz, Lucrecia</creator><general>Sciendo</general><general>De Gruyter Poland</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20220401</creationdate><title>Change in levothyroxine requirements after bariatric surgery in patients with hypothyroidism</title><author>Garcia-Moreno, Rosa Maria ; Cos-Blanco, Ana Isabel ; Calvo-Vinuela, Isabel ; Zapatero-Larrauri, Miriam ; Herranz, Lucrecia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3221-e1fa5a6135ce773dfb8f24433aff06f48fdf8d1d6f9c9434bb7657fde26293463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bariatric Surgery</topic><topic>Gastrointestinal surgery</topic><topic>Humans</topic><topic>Hypothyroidism</topic><topic>Hypothyroidism - drug therapy</topic><topic>levothyroxine</topic><topic>Retrospective Studies</topic><topic>Thyroxine - therapeutic use</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia-Moreno, Rosa Maria</creatorcontrib><creatorcontrib>Cos-Blanco, Ana Isabel</creatorcontrib><creatorcontrib>Calvo-Vinuela, Isabel</creatorcontrib><creatorcontrib>Zapatero-Larrauri, Miriam</creatorcontrib><creatorcontrib>Herranz, Lucrecia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Endocrine regulations (Bratislava)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia-Moreno, Rosa Maria</au><au>Cos-Blanco, Ana Isabel</au><au>Calvo-Vinuela, Isabel</au><au>Zapatero-Larrauri, Miriam</au><au>Herranz, Lucrecia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Change in levothyroxine requirements after bariatric surgery in patients with hypothyroidism</atitle><jtitle>Endocrine regulations (Bratislava)</jtitle><addtitle>Endocr Regul</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>56</volume><issue>2</issue><spage>81</spage><epage>86</epage><pages>81-86</pages><issn>1336-0329</issn><issn>1210-0668</issn><eissn>1336-0329</eissn><abstract>This study aims to evaluate the need to modify the total and weight-adjusted doses of levothyroxine after bariatric surgery, identify predictors, and assess the influence of the weight loss on the levothyroxine requirements.
A retrospective study in patients with treated hypothyroidism that underwent bariatric surgery. The modification of the levothyroxine dose and its association with the weight loss and other potential predictors were evaluated at 6, 12, and 24 months post-surgery.
Among the 63 patients included, 82.54% needed an adjustment of levothyroxine dose during the follow-up. The total weekly dose of levothyroxine (µg) decreased post-surgery at 6 months (β= −49.1; 95%CI-93.7 to −4.5; p=0.031) and 12 months (β=−54.9; 95%CI-102 to −7.8; p=0.022), but did not significantly change at 24 months (p=0.114). The weekly weight-adjusted dose (µg/k) increased at 6 months (β=1.37; 95%CI 0.91 to 1.83; p<0.001), 12 months (β=2.05; 95%CI 1.43 to 2.67; p<0.001), and 24 months (β=2.52; 95%CI 1.74 to 3.30; p<0.001). The weight loss showed association with the weight-adjusted dose (OR=1.07; 95%CI 1.02 to 1.12; p=0.004), but not the total dose (p=0.320).
This study shows a significant decrease in the total dose of levothyroxine requirements change after bariatric surgery during the first year of the follow-up and an increase in the weight-adjusted dose over the first two years. No predictors of modification of the total dose of levothyroxine were identified.</abstract><cop>Germany</cop><pub>Sciendo</pub><pmid>35489047</pmid><doi>10.2478/enr-2022-0009</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1336-0329 |
| ispartof | Endocrine regulations (Bratislava), 2022-04, Vol.56 (2), p.81-86 |
| issn | 1336-0329 1210-0668 1336-0329 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_876f28d69d734af89517b4a31a7c4a9c |
| source | DOAJ Directory of Open Access Journals |
| subjects | Bariatric Surgery Gastrointestinal surgery Humans Hypothyroidism Hypothyroidism - drug therapy levothyroxine Retrospective Studies Thyroxine - therapeutic use Weight Loss |
| title | Change in levothyroxine requirements after bariatric surgery in patients with hypothyroidism |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T21%3A48%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Change%20in%20levothyroxine%20requirements%20after%20bariatric%20surgery%20in%20patients%20with%20hypothyroidism&rft.jtitle=Endocrine%20regulations%20(Bratislava)&rft.au=Garcia-Moreno,%20Rosa%20Maria&rft.date=2022-04-01&rft.volume=56&rft.issue=2&rft.spage=81&rft.epage=86&rft.pages=81-86&rft.issn=1336-0329&rft.eissn=1336-0329&rft_id=info:doi/10.2478/enr-2022-0009&rft_dat=%3Cproquest_doaj_%3E2658229143%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3221-e1fa5a6135ce773dfb8f24433aff06f48fdf8d1d6f9c9434bb7657fde26293463%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3156561192&rft_id=info:pmid/35489047&rfr_iscdi=true |