Clinical and prognostic aspects of patients with the Neuromyelitis Optica Spectrum Disorder (NMOSD) from a cohort in Northeast Brazil

Neuromyelitis optica spectrum disorders (NMOSD) is a rare inflammatory and demyelinating disease of the central nervous system (CNS) more frequent in women and Afro-descendants. No previous epidemiological or prognostic study has been conducted in the region of the state of Bahia, Brazilian Northeas...

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Published in:BMC neurology 2022-03, Vol.22 (1), p.95-95, Article 95
Main Authors: Fukuda, Thiago Gonçalves, Silva, Ivã Taiuan Fialho, Dos Santos, Tayla Samanta Silva, Filho, Marcos Baruch Portela, de Abreu, Fernanda Ferreira, Oliveira-Filho, Jamary
Format: Article
Language:English
Subjects:
Adult
Aquaporin 4
Brazil - epidemiology
Brazilian Northeast
Complications and side effects
Demographic aspects
Development and progression
Diagnosis
Dyslipidemias
Female
Health aspects
Humans
Male
Middle Aged
Neuromyelitis optica
Neuromyelitis Optica - complications
Neuromyelitis Optica - diagnosis
Neuromyelitis Optica - epidemiology
Neuromyelitis optica spectrum disorders
Prognosis
Prognostic factors
Retrospective Studies
Women
Young Adult
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Summary:Neuromyelitis optica spectrum disorders (NMOSD) is a rare inflammatory and demyelinating disease of the central nervous system (CNS) more frequent in women and Afro-descendants. No previous epidemiological or prognostic study has been conducted in the region of the state of Bahia, Brazilian Northeast. To evaluate clinical and prognostic aspects in patients with NMOSD from a cohort in northeastern Brazil. A single-center retrospective study was conducted with consecutive patients diagnosed with NMOSD. Clinical and epidemiological characteristics were described. The degree of disability was expressed by the Expanded Disability Status Scale (EDSS). Worsening disability were analyzed through negative binomial regression adjusted for disease duration. Ninety-one patients were included, 72 (79.1%) female and 67 (73.6%) afro descendants. Mean age at onset was 36 (± 14) years and 73.3% were anti-aquaporin-4 antibody positive. Isolated transverse myelitis (32.9%) and isolated optic neuritis (22.4%) were the most frequent initial clinical syndromes. After multivariate analysis, optic neuritis (RR = 0.45; 95% CI = 0.23 - 0.88; p = 0.020) and dyslipidemia (RR = 0.40; 95% CI = 0.20 - 0.83; p = 0.014) were associated with slower disease progression. Area postrema involvement (RR = 6.70; 95% CI = 3.31 - 13.54; p 
ISSN:1471-2377
1471-2377
DOI:10.1186/s12883-022-02621-5