Integrating Systematic Reviews into Supportive Care Trial Design: The Rethinking Clinical Trials (REaCT) Program

To review the successes and challenges of integrating systematic reviews (SRs) into the Rethinking Clinical Trials (REaCT) Program. All REaCT program SRs were evaluated and descriptive summaries presented. Twenty-two SRs have been performed evaluating standard of care interventions for the managemen...

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Bibliographic Details
Published in:Current oncology (Toronto) 2022-12, Vol.29 (12), p.9550-9559
Main Authors: Alshamsan, Bader, Hutton, Brian, Liu, Michelle, Vandermeer, Lisa, Clemons, Mark
Format: Article
Language:English
Subjects:
breast cancer
Breast Neoplasms - therapy
clinical trial
Clinical trials
Female
Humans
Hutton, Brian
meta-analysis
network meta-analysis
pragmatic trial
Prostate cancer
Research Design
Review
systematic review
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Summary:To review the successes and challenges of integrating systematic reviews (SRs) into the Rethinking Clinical Trials (REaCT) Program. All REaCT program SRs were evaluated and descriptive summaries presented. Twenty-two SRs have been performed evaluating standard of care interventions for the management of: breast cancer ( = 15), all tumour sites ( = 4), breast and prostate cancers ( = 2), and prostate cancer ( = 1). The majority of SRs were related to supportive care ( = 14) and survivorship ( = 5) interventions and most (19/22, 86%) confirmed the existence of uncertainty relating to the clinical question addressed in the SR. Most SRs (15/22, 68%) provided specific recommendations for future studies and results were incorporated into peer-reviewed grant applications ( = 6) and clinical trial design ( = 12). In 12/22 of the SRs, the first author was a trainee. All SRs followed PRISMA guidelines. SRs are important for identifying and confirming clinical equipoise and designing trials. SRs provide an excellent opportunity for trainees to participate in research.
ISSN:1718-7729
1198-0052
1718-7729
DOI:10.3390/curroncol29120750