Preclinical gout is common in the patient with stage 3–5 chronic kidney disease. Relevance of musculoskeletal ultrasound

One in 10 patients with hyperuricemia may develop gout over time, with urate deposition sometimes asymptomatic. Recent reviews and guidelines support ultrasound (US) to assess asymptomatic hyperuricemic (AH) patients to detect gout lesions, showing double contour (DC) and tophus the highest specific...

Full description

Saved in:
Bibliographic Details
Published in:Nefrología 2024-11, Vol.44 (6), p.877-884
Main Authors: Calvo-Aranda, Enrique, Barrio Nogal, Laura, Blanco Caceres, Boris Anthony, Peiteado, Diana, Novella-Navarro, Marta, De Miguel, Eugenio, Arroyo Palomo, Jaime, Alcázar Arroyo, Roberto, Martín Navarro, Juan Antonio, Fernandez Lucas, Milagros, Diaz Dominguez, Martha Elizabeth, Vaca Gallardo, Marco Antonio, Besada Estevez, Elda, Lojo Oliveira, Leticia
Format: Article
Language:English
Subjects:
Aged
Asymptomatic Diseases
Chronic kidney disease
Cross-Sectional Studies
Ecografía musculoesquelética
Enfermedad renal crónica
Female
Glomerular Filtration Rate
Gota preclínica
Gout - complications
Gout - diagnostic imaging
Humans
Hyperuricemia - complications
Hyperuricemia - epidemiology
Male
Middle Aged
Musculoskeletal ultrasound
Preclinical gout
Prevalence
Renal Insufficiency, Chronic - complications
Severity of Illness Index
Ultrasonography
Urate
Urato
Uric acid
Uric Acid - blood
Ácido úrico
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:One in 10 patients with hyperuricemia may develop gout over time, with urate deposition sometimes asymptomatic. Recent reviews and guidelines support ultrasound (US) to assess asymptomatic hyperuricemic (AH) patients to detect gout lesions, showing double contour (DC) and tophus the highest specificities and positive predictive values. Hyperuricemia and gout are common in chronic kidney disease (CKD), especially with glomerular filtration rate (GFR) 7 mg/dl, documented at least twice during the last 12 months. A standardized US exam of the knees and bilateral first metatarsophalangeal joints was performed to assess patients for DC/tophus as defined by OMERACT. Demographic, clinical and laboratory data were recorded. A descriptive analysis was performed using SPSS. Pre-clinical gout (PCG: DC and/or tophus) was considered as outcome variable. Chi-square and Fisher's exact test were used for qualitative variables, and Mann–Whitney U test for quantitative variables; significant threshold p 
ISSN:2013-2514
2013-2514
DOI:10.1016/j.nefroe.2024.11.006