Associations of BRAP polymorphisms with the risk of alcohol dependence and scores on the Alcohol Use Disorders Identification Test

• Published in: Neuropsychiatric disease and treatment 2019-01, Vol.15, p.83-94
• Main Authors: Kim, Jee Wook, Choe, Young Min, Shin, Joong-Gon, Park, Byung Lae, Shin, Hyung-Doo, Choi, Ihn-Geun, Lee, Boung Chul
• Format: Article
• Language: English
• Subjects: Age; Alcohol dependence; Alcohol use; Alcoholism; AUDIT; BRAP; Deoxyribonucleic acid; DNA; DNA methylation; Gene loci; Genetic aspects; Genetic polymorphisms; Genome-wide association studies; genome-wide association study; Genomes; Health aspects; Hospitals; Kinases; Males; Mental disorders; Metabolism; Neurosciences; Original Research; Population; Proteins; Risk factors; Schizophrenia; single nucleotide polymorphism; Software
• ISSN: 1176-6328; 1178-2021; 1178-2021
• DOI: 10.2147/NDT.S184067

Alcohol dependence (AD) is a common disorder that is influenced by genetic as well as environmental factors. A previous genome-wide association study (GWAS) of the Korean population performed by our research group identified a number of genes, including ( ) and ( ), as novel genetic markers of AD. The present investigation was a fine-mapping follow-up study of 459 AD and 455 non-AD subjects of Korean descent to determine the associations between and polymorphisms and AD. The Alcohol Use Disorders Identification Test (AUDIT) was administered to screen for the degree of AD risk in the subjects and 58 genetic variants, 5 for and 53 for , were genotyped for subsequent association analyses. In the present case-control analysis, showed the most significant association signal with a risk of AD ( =1.29×10 , =7.74×10 , OR =0.19). There were also significant differences in the overall and subcategory scores for the genetic variants, including ( =9.94×10 , =5.96×10 at for the overall AUDIT score). However, the genetic effects of polymorphisms observed in our previous GWAS were not replicated in the present study (minimum =0.0005, >0.05, OR =0.30 at in the recessive model). Furthermore, the single-nucleotide polymorphisms of were not associated with the overall and subcategory AUDIT scores. The present findings suggest that the genetic variants of may contribute to a predisposition for an alcohol use disorder.