Taurine and vitamin E supplementations have minimal effects on body composition, hepatic lipids, and blood hormone and metabolite concentrations in healthy Sprague Dawley rats

• Published in: Nutrition and dietary supplements 2015-01, Vol.7 (default), p.77-85
• Main Authors: Allen, Portia S, Brown, Andrew W, Brown, Michelle M Bohan, Hsu, Walter H, Beitz, Donald C
• Format: Article
• Language: English
• Subjects: Antidiabetics; Body composition; Dietary supplements; Functional foods; Health aspects; Kinases; Lipids; Metabolites; Pharmaceuticals; Physiological aspects; Taurine; Vitamin E
• ISSN: 1179-1489; 1179-1489
• DOI: 10.2147/NDS.S88888

As prescriptions for off-label pharmaceutical use and autonomous administration of over-the-counter nutraceuticals become mainstream, thorough assessments of these compounds are warranted. To determine the effects of gemfibrozil, rosiglitazone, metformin, taurine, and vitamin E on body composition, hepatic lipids, and metabolic hormone and blood metabolite concentrations in a healthy, outbred rat cohort. Male Sprague Dawley rats were fed a purified 10 kcal% from fat diet for 56 days and assigned to diet alone (control) or diet plus oral administration of gemfibrozil (34 mg/kg), metformin (500 mg/kg), rosiglitazone (3 mg/kg), taurine (520 mg/kg), or vitamin E (200 mg/kg). Rosiglitazone administration resulted in a 56% increase in carcass adiposity, cautioning potential prescriptive off-label use. Taurine supplementation had no adverse effects on evaluated parameters. A modest but significant increase in liver triacylglycerol content was observed with vitamin E supplementation compared with control (Δ 17.2 g triacylglycerol/100 g liver lipid). The evaluated pharmaceuticals had effects in a healthy population similar to the reported effects in their target population and the nutraceuticals had minimal effects on the measured physiological parameters.