Higher Adiposity Is Associated With Slower Cognitive Decline in Hypertensive Patients: Secondary Analysis of the China Stroke Primary Prevention Trial

Background Obesity is a risk factor for many diseases. However, the potential association between adiposity and cognitive decline in hypertensive patients is inconclusive. We performed a secondary data analysis of the CSPPT (China Stroke Primary Prevention Trial) to examine whether adiposity is corr...

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Bibliographic Details
Published in:Journal of the American Heart Association 2017-10, Vol.6 (10), p.n/a
Main Authors: Zhang, Jun, Tang, Genfu, Xie, Haiqun, Wang, Binyan, He, Mingli, Fu, Jia, Shi, Xiuli, Zhang, Chengguo, Huo, Yong, Xu, Xiping, Wang, Kai
Format: Article
Language:English
Subjects:
Adiposity
Aged
Antihypertensive Agents - therapeutic use
Blood Pressure - drug effects
Body Mass Index
Chi-Square Distribution
China - epidemiology
Cognition
Cognition Disorders - diagnosis
Cognition Disorders - epidemiology
Cognition Disorders - psychology
cognitive decline
Female
Humans
hypertension
Hypertension - diagnosis
Hypertension - drug therapy
Hypertension - epidemiology
Hypertension - physiopathology
Linear Models
Longitudinal Studies
Male
Mental Status and Dementia Tests
Middle Aged
Multivariate Analysis
Nonlinear Dynamics
Obesity - diagnosis
Obesity - epidemiology
Obesity - physiopathology
Original Research
Primary Prevention - methods
Proportional Hazards Models
Protective Factors
Risk Factors
Stroke - diagnosis
Stroke - epidemiology
Stroke - prevention & control
Time Factors
Waist Circumference
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Summary:Background Obesity is a risk factor for many diseases. However, the potential association between adiposity and cognitive decline in hypertensive patients is inconclusive. We performed a secondary data analysis of the CSPPT (China Stroke Primary Prevention Trial) to examine whether adiposity is correlated with longitudinal cognitive performance in hypertensive adults. Methods and Results The analysis included 16 791 patients in the CSPPT who received at least 2 cognitive assessments by the Mini‐Mental State Examination (MMSE) during the follow‐up (median, 4.5 years; interquartile range, 4.2–4.8 years). Outcomes included changes in MMSE scores and cognitive impairment (defined as MMSE score less than education‐specific cutoff point). A marked reduction in MMSE scores at the final (compared with at the 1‐year) follow‐up was apparent in both men (n=4838; mean [SD] score, 0.41 [3.62]) and women (n=7190; mean [SD] score, 1.07 [4.61]; both P
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.117.005561