The Beneficial Effects of Natural Extracts and Bioactive Compounds on the Gut-Liver Axis: A Promising Intervention for Alcoholic Liver Disease

Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. It can cause fatty liver (steatosis), steatohepatitis, fibrosis, cirrhosis, and liver cancer. Alcohol consumption can also disturb the composition of gut microbiota, increasing the composition of harmful microbes an...

Full description

Saved in:
Bibliographic Details
Published in:Antioxidants 2022-06, Vol.11 (6), p.1211
Main Authors: Zhao, Liang, Wang, Shaoxuan, Zhang, Nanhai, Zhou, Jingxuan, Mehmood, Arshad, Raka, Rifat Nowshin, Zhou, Feng, Zhao, Lei
Format: Article
Language:English
Subjects:
Acids
Alcohol use
alcoholic liver disease
Bacteria
Bile
Bioactive compounds
Cancer therapies
Cirrhosis
Cytokines
Dietary supplements
Digestive system
Dysbacteriosis
Endotoxemia
Fatty liver
Fibrosis
Gastrointestinal tract
gut microbiota
gut-liver axis
Inflammation
Information processing
Intestinal microflora
Liver cancer
Liver cirrhosis
Liver diseases
Metabolic disorders
Metabolism
Microbiota
Morbidity
Mortality
Natural products
Pathogenesis
Permeability
Polyphenols
Review
Steatosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. It can cause fatty liver (steatosis), steatohepatitis, fibrosis, cirrhosis, and liver cancer. Alcohol consumption can also disturb the composition of gut microbiota, increasing the composition of harmful microbes and decreasing beneficial ones. Restoring eubiosis or preventing dysbiosis after alcohol consumption is an important strategy in treating ALD. Plant natural products and polyphenolic compounds exert beneficial effects on several metabolic disorders associated with ALD. Natural products and related phytochemicals act through multiple pathways, such as modulating gut microbiota, improving redox stress, and anti-inflammation. In the present review article, we gather information on natural extract and bioactive compounds on the gut-liver axis for the possible treatment of ALD. Supplementation with natural extracts and bioactive compounds promoted the intestinal tight junction, protected against the alcohol-induced gut leakiness and inflammation, and reduced endotoxemia in alcohol-exposed animals. Taken together, natural extracts and bioactive compounds have strong potential against ALD; however, further clinical studies are still needed.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox11061211