The Neutrophil-to-Monocyte Ratio and Platelet-to-White Blood Cell Ratio Represent Novel Prognostic Markers in Patients with Pancreatic Cancer

Background. Inflammation plays an important role in the development of tumors. Several serum based-markers and ratios have been investigated for their prognostic value in pancreatic cancer. However, the prognostic value of the neutrophil-to-monocyte ratio (NMR) and platelet-to-white blood cell ratio...

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Published in:Gastroenterology research and practice 2021, Vol.2021, p.6693028-9
Main Authors: Tang, Feng, Dai, Penghui, Wei, Qiongqiong, Gan, Ke, Wang, Zijie, Chen, Huan, Li, Ting, Lv, Muhan, Deng, Mingming, Luo, Gang
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Language:English
Subjects:
Blood
Blood platelets
Cancer
Care and treatment
Comparative analysis
Development and progression
Inflammation
Lymphocytes
Medical prognosis
Neutrophils
Nuclear magnetic resonance
Pancreatic cancer
Prognosis
Tumors
Variables
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container_title Gastroenterology research and practice
container_volume 2021
creator Tang, Feng
Dai, Penghui
Wei, Qiongqiong
Gan, Ke
Wang, Zijie
Chen, Huan
Li, Ting
Lv, Muhan
Deng, Mingming
Luo, Gang
description Background. Inflammation plays an important role in the development of tumors. Several serum based-markers and ratios have been investigated for their prognostic value in pancreatic cancer. However, the prognostic value of the neutrophil-to-monocyte ratio (NMR) and platelet-to-white blood cell ratio (PWR) for patients with pancreatic cancer has scarcely been investigated. Methods. From October 2013 to November 2018, a retrospective cohort study was performed on 269 pancreatic cancer patients without treatment. Receiver operating characteristic curves were generated, and areas under the curve were compared for the evaluation of the discriminatory ability of inflammation-based prognostic scoring systems. Kaplan-Meier curves and the Cox proportional hazard model were employed to analyze the relationships among NMR, PWR, and overall survival (OS). Results. The optimal cutoff values of NMR and PWR were 48 and 6, respectively. In univariate analysis, the survival time of NMR>48 and PWR≤6 was shorter than that of NMR≤48 and PWR>6 in patients with pancreatic cancer (P
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Inflammation plays an important role in the development of tumors. Several serum based-markers and ratios have been investigated for their prognostic value in pancreatic cancer. However, the prognostic value of the neutrophil-to-monocyte ratio (NMR) and platelet-to-white blood cell ratio (PWR) for patients with pancreatic cancer has scarcely been investigated. Methods. From October 2013 to November 2018, a retrospective cohort study was performed on 269 pancreatic cancer patients without treatment. Receiver operating characteristic curves were generated, and areas under the curve were compared for the evaluation of the discriminatory ability of inflammation-based prognostic scoring systems. Kaplan-Meier curves and the Cox proportional hazard model were employed to analyze the relationships among NMR, PWR, and overall survival (OS). Results. The optimal cutoff values of NMR and PWR were 48 and 6, respectively. In univariate analysis, the survival time of NMR&gt;48 and PWR≤6 was shorter than that of NMR≤48 and PWR&gt;6 in patients with pancreatic cancer (P&lt;0.001). In Cox univariate and multivariate analyses, NMR (hazard ratio (HR), 9.095; 95% confidence interval (CI), 3.64–22.72; P&lt;0.001) and PWR (HR, 8.230; 95% CI, 3.32–20.43; P&lt;0.001) were significantly correlated with OS. Conclusions. The current study demonstrated that NMR and PWR may serve as novel and promising inflammatory prognostic scores for patients with pancreatic cancer. Elevated NMR (&gt;48) and depressed PWR (&lt;6) were independently associated with poor prognosis in patients with pancreatic cancer.</description><identifier>ISSN: 1687-6121</identifier><identifier>EISSN: 1687-630X</identifier><identifier>DOI: 10.1155/2021/6693028</identifier><identifier>PMID: 34122538</identifier><language>eng</language><publisher>Egypt: Hindawi</publisher><subject>Blood ; Blood platelets ; Cancer ; Care and treatment ; Comparative analysis ; Development and progression ; Inflammation ; Lymphocytes ; Medical prognosis ; Neutrophils ; Nuclear magnetic resonance ; Pancreatic cancer ; Prognosis ; Tumors ; Variables</subject><ispartof>Gastroenterology research and practice, 2021, Vol.2021, p.6693028-9</ispartof><rights>Copyright © 2021 Feng Tang et al.</rights><rights>COPYRIGHT 2021 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2021 Feng Tang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Feng Tang et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-804f0adc00d6ebbbe8f40742b7585ec592e4853e008f32bfd784beab444f5d933</citedby><cites>FETCH-LOGICAL-c581t-804f0adc00d6ebbbe8f40742b7585ec592e4853e008f32bfd784beab444f5d933</cites><orcidid>0000-0001-9522-9649 ; 0000-0002-2234-6542 ; 0000-0001-9454-7645</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2537374796/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2537374796?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,4012,25742,27912,27913,27914,37001,37002,44579,53780,53782,74885</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34122538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Silvestris, Nicola</contributor><contributor>Nicola Silvestris</contributor><creatorcontrib>Tang, Feng</creatorcontrib><creatorcontrib>Dai, Penghui</creatorcontrib><creatorcontrib>Wei, Qiongqiong</creatorcontrib><creatorcontrib>Gan, Ke</creatorcontrib><creatorcontrib>Wang, Zijie</creatorcontrib><creatorcontrib>Chen, Huan</creatorcontrib><creatorcontrib>Li, Ting</creatorcontrib><creatorcontrib>Lv, Muhan</creatorcontrib><creatorcontrib>Deng, Mingming</creatorcontrib><creatorcontrib>Luo, Gang</creatorcontrib><title>The Neutrophil-to-Monocyte Ratio and Platelet-to-White Blood Cell Ratio Represent Novel Prognostic Markers in Patients with Pancreatic Cancer</title><title>Gastroenterology research and practice</title><addtitle>Gastroenterol Res Pract</addtitle><description>Background. Inflammation plays an important role in the development of tumors. Several serum based-markers and ratios have been investigated for their prognostic value in pancreatic cancer. However, the prognostic value of the neutrophil-to-monocyte ratio (NMR) and platelet-to-white blood cell ratio (PWR) for patients with pancreatic cancer has scarcely been investigated. Methods. From October 2013 to November 2018, a retrospective cohort study was performed on 269 pancreatic cancer patients without treatment. Receiver operating characteristic curves were generated, and areas under the curve were compared for the evaluation of the discriminatory ability of inflammation-based prognostic scoring systems. Kaplan-Meier curves and the Cox proportional hazard model were employed to analyze the relationships among NMR, PWR, and overall survival (OS). Results. The optimal cutoff values of NMR and PWR were 48 and 6, respectively. In univariate analysis, the survival time of NMR&gt;48 and PWR≤6 was shorter than that of NMR≤48 and PWR&gt;6 in patients with pancreatic cancer (P&lt;0.001). In Cox univariate and multivariate analyses, NMR (hazard ratio (HR), 9.095; 95% confidence interval (CI), 3.64–22.72; P&lt;0.001) and PWR (HR, 8.230; 95% CI, 3.32–20.43; P&lt;0.001) were significantly correlated with OS. Conclusions. The current study demonstrated that NMR and PWR may serve as novel and promising inflammatory prognostic scores for patients with pancreatic cancer. Elevated NMR (&gt;48) and depressed PWR (&lt;6) were independently associated with poor prognosis in patients with pancreatic cancer.</description><subject>Blood</subject><subject>Blood platelets</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Comparative analysis</subject><subject>Development and progression</subject><subject>Inflammation</subject><subject>Lymphocytes</subject><subject>Medical prognosis</subject><subject>Neutrophils</subject><subject>Nuclear magnetic resonance</subject><subject>Pancreatic cancer</subject><subject>Prognosis</subject><subject>Tumors</subject><subject>Variables</subject><issn>1687-6121</issn><issn>1687-630X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kk1vEzEQhlcIREvgxhmtxAUJtvX3ei-VSsRHpbZEVRHcLK89m3XZ2MHetOqP4D_jkLQQhJAPtmeeee13NEXxHKMDjDk_JIjgQyEaioh8UOxjIetKUPT14d0ZE7xXPEnpCiFBEOKPiz3KMCGcyv3ix2UP5TmsxhiWvRuqMVRnwQdzO0J5oUcXSu1tORv0CAOM6_SX3uXc2yEEW05hGLbYBSwjJPBjeR6uYShnMcx9SKMz5ZmO3yCm0vlyltnMpPLGjX2-eRNBr5lpPkJ8Wjzq9JDg2XafFJ_fv7ucfqxOP304mR6fVoZLPFYSsQ5paxCyAtq2BdkxVDPS1lxyMLwhwCSngJDsKGk7W0vWgm4ZYx23DaWT4mSja4O-UsvoFjreqqCd-hUIca50zN8aQMkWE0bBtp3gTAurLWWWW2oahLo660-Ko43WctUuwJpsL-phR3Q3412v5uFaSSwaIngWeLUViOH7CtKoFi6Z3FntIaySIjybI4w0TUZf_oVehVX0uVWZojWtWd2I39RcZwPOdyG_a9ai6lg0QjacEZmpg39QeVlYOBM8dC7HdwrebApMDClF6O49YqTWo6jWo6i2o5jxF3_25R6-m70MvN4AvfNW37j_y_0EWv_mqQ</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Tang, Feng</creator><creator>Dai, Penghui</creator><creator>Wei, Qiongqiong</creator><creator>Gan, Ke</creator><creator>Wang, Zijie</creator><creator>Chen, Huan</creator><creator>Li, Ting</creator><creator>Lv, Muhan</creator><creator>Deng, Mingming</creator><creator>Luo, Gang</creator><general>Hindawi</general><general>John Wiley &amp; 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Inflammation plays an important role in the development of tumors. Several serum based-markers and ratios have been investigated for their prognostic value in pancreatic cancer. However, the prognostic value of the neutrophil-to-monocyte ratio (NMR) and platelet-to-white blood cell ratio (PWR) for patients with pancreatic cancer has scarcely been investigated. Methods. From October 2013 to November 2018, a retrospective cohort study was performed on 269 pancreatic cancer patients without treatment. Receiver operating characteristic curves were generated, and areas under the curve were compared for the evaluation of the discriminatory ability of inflammation-based prognostic scoring systems. Kaplan-Meier curves and the Cox proportional hazard model were employed to analyze the relationships among NMR, PWR, and overall survival (OS). Results. The optimal cutoff values of NMR and PWR were 48 and 6, respectively. In univariate analysis, the survival time of NMR&gt;48 and PWR≤6 was shorter than that of NMR≤48 and PWR&gt;6 in patients with pancreatic cancer (P&lt;0.001). In Cox univariate and multivariate analyses, NMR (hazard ratio (HR), 9.095; 95% confidence interval (CI), 3.64–22.72; P&lt;0.001) and PWR (HR, 8.230; 95% CI, 3.32–20.43; P&lt;0.001) were significantly correlated with OS. Conclusions. The current study demonstrated that NMR and PWR may serve as novel and promising inflammatory prognostic scores for patients with pancreatic cancer. Elevated NMR (&gt;48) and depressed PWR (&lt;6) were independently associated with poor prognosis in patients with pancreatic cancer.</abstract><cop>Egypt</cop><pub>Hindawi</pub><pmid>34122538</pmid><doi>10.1155/2021/6693028</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9522-9649</orcidid><orcidid>https://orcid.org/0000-0002-2234-6542</orcidid><orcidid>https://orcid.org/0000-0001-9454-7645</orcidid><oa>free_for_read</oa></addata></record>
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subjects Blood
Blood platelets
Cancer
Care and treatment
Comparative analysis
Development and progression
Inflammation
Lymphocytes
Medical prognosis
Neutrophils
Nuclear magnetic resonance
Pancreatic cancer
Prognosis
Tumors
Variables
title The Neutrophil-to-Monocyte Ratio and Platelet-to-White Blood Cell Ratio Represent Novel Prognostic Markers in Patients with Pancreatic Cancer
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