Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice

Liver injury is a common complication of inflammatory bowel disease (IBD). However, the mechanisms of liver injury development are not clear in IBD patients. Gut microbiota is thought to be engaged in IBD pathogenesis. Here, by an integrated analysis of host transcriptome and colonic microbiome, we...

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Bibliographic Details
Published in:Frontiers in immunology 2022-01, Vol.12, p.773070-773070
Main Authors: Zhu, Luoyi, Zong, Xin, Xiao, Xiao, Cheng, Yuanzhi, Fu, Jie, Lu, Zeqing, Jin, Mingliang, Wang, Fengqin, Wang, Yizhen
Format: Article
Language:English
Subjects:
Animals
Colitis - chemically induced
Colitis - immunology
Colitis - microbiology
Colon - immunology
Colon - microbiology
Dextran Sulfate - toxicity
Disease Models, Animal
Gastrointestinal Microbiome - immunology
gene regulation
gut microbiota
host-microbe interactions
IBD
Immunology
Inflammatory Bowel Diseases - chemically induced
Inflammatory Bowel Diseases - immunology
Inflammatory Bowel Diseases - microbiology
Liver - immunology
Liver - injuries
Liver - microbiology
liver injury
Mice
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Summary:Liver injury is a common complication of inflammatory bowel disease (IBD). However, the mechanisms of liver injury development are not clear in IBD patients. Gut microbiota is thought to be engaged in IBD pathogenesis. Here, by an integrated analysis of host transcriptome and colonic microbiome, we have attempted to reveal the mechanism of liver injury in colitis mice. In this study, dextran sulfate sodium (DSS) -induced mice colitis model was constructed. Liver transcriptome showed significant up- and down-regulation of pathways linked to immune response and lipid metabolism, respectively. Whilst the colon transcriptome exhibited dramatic alterations in immune response and pathways associated with cell growth and death. The microbiota of DSS-treated mice underwent strong transitions. Correlation analyses identified genes associated with liver and colon injury, whose expression was associated with the abundance of liver and gut health-related bacteria. Collectively, the results indicate that the liver injury in colitis mice may be related to the intestinal dysbiosis and host-microbiota interactions. These findings may provide new insights for identifying potential targets for the treatment of IBD and its induced liver injury.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.773070