Non‐pharmacological interventions for asthma prevention and management across the life course: Umbrella review

• Published in: Clinical and translational allergy 2024-03, Vol.14 (3), p.e12344-n/a
• Main Authors: Tong, Xunliang, Zhang, Xinyue, Wang, Mengyuan, Wang, Zijun, Dong, Fawu, Gong, Enying, Zuberbier, Torsten, Li, Yanming
• Format: Article
• Language: English
• Subjects: Age groups; Asthma; Child development; Chronic illnesses; Gastrointestinal surgery; Health education; Intervention; life course; Medical personnel; non‐pharmacological interventions; Prevention; Quality of life; Risk factors; Systematic review; umbrella review
• ISSN: 2045-7022; 2045-7022
• DOI: 10.1002/clt2.12344

Background The impact of non‐pharmacological interventions (NPIs) on asthma prevention and management is insufficiently examined. We aim to comprehensively evaluate and synthesize existing evidence regarding the effectiveness of various NPIs throughout the life course. Methods We conducted a systematic search and screening of reviews that examined the effectiveness of various NPIs on asthma prevention and control in the Cochrane Library, PubMed, Embase, and Ovid databases. Data extraction was performed by considering the type of NPIs and the life course stages of the target population. Recommendations were provided by considering the quality of review assessed using the AMSTAR2 tool and the consistency of findings across reviews. Results We identified 145 reviews and mapped the evidence on the impact of 25 subtypes of NPIs on asthma prevention and control based on five stages of life course. Reviews indicated a shift of focus and various impacts of major NPIs on asthma prevention and control across life courses, while a few types of NPIs, such as physical exercise, appeared to be beneficial in children, adolescents and adults. Consistent and high‐level evidence was observed only for psychological intervention on asthma control and quality of life among adults and older adults. Potential benefit with high‐level evidence was reported on certain NPIs, such as vitamin D in reducing risk of developing asthma in offsprings in the prenatal stage, digital health interventions in improving asthma control from childhood to older adulthood, and breathing exercise in improving quality of life, asthma‐related symptoms and lung function in adulthood and older adulthood. Conclusion This study emphasizes the significance of delivering NPIs to improve asthma prevention and management and highlights the heterogeneity regarding the impact of NPIs across life courses. High‐quality research is urgently needed to further strengthen the evidence base of NPIs and tailored interventions should be considered in guideline development.